Citation: Jin Jiang, Jiu Yu Liu, Hui Yuan Guo. The synthesis and activity in vitro of a series of 8-difluoromethoxy quinolones:Analogues of gemifloxacin[J]. Chinese Chemical Letters, ;2007, 18(10): 1169-1172. doi: 10.1016/j.cclet.2007.07.030 shu

The synthesis and activity in vitro of a series of 8-difluoromethoxy quinolones:Analogues of gemifloxacin

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing 100050, China

Received Date: 7 June 2007

Fund Project: The authors would like to thank the National Research Center of Drug and Metabolite Analysis for measuring the data of ¹H NMR,ESI-MS and HRESI-MS.We also want to thank the pharmacology laboratory of Institute of Medicinal Biotechnology for testing the antibacterial activity.

7-[4-(Aminomethyl)-3-(methoxyimino)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-difluoromethoxy-1, 4-dihydro-4-oxoquino-line-3-carboxylic acid and its analogues have been prepared and evaluated for antibacterial activity in vitro.
- Quinolone,
- Synthesis,
- Antibacterial activity
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