引用本文:
Kun Zou, Jun Zhi Wang, Jun Wu, Yuan Zhou, Chuang Liu, Fei Jun Dan, Ya Xiong Zhang, Jin Yang. Furostanol saponins with inhibitory action against COX-2 production from Tupistra chinensis rhizomes[J]. Chinese Chemical Letters,
2007, 18(10): 1239-1242.
doi:
10.1016/j.cclet.2007.06.018
Citation: Kun Zou, Jun Zhi Wang, Jun Wu, Yuan Zhou, Chuang Liu, Fei Jun Dan, Ya Xiong Zhang, Jin Yang. Furostanol saponins with inhibitory action against COX-2 production from Tupistra chinensis rhizomes[J]. Chinese Chemical Letters, 2007, 18(10): 1239-1242. doi: 10.1016/j.cclet.2007.06.018
Citation: Kun Zou, Jun Zhi Wang, Jun Wu, Yuan Zhou, Chuang Liu, Fei Jun Dan, Ya Xiong Zhang, Jin Yang. Furostanol saponins with inhibitory action against COX-2 production from Tupistra chinensis rhizomes[J]. Chinese Chemical Letters, 2007, 18(10): 1239-1242. doi: 10.1016/j.cclet.2007.06.018
Furostanol saponins with inhibitory action against COX-2 production from Tupistra chinensis rhizomes
摘要:
Two furostanol saponins were obtained from the n-butanol fraction of methanol extract from Tupistra chinensis rhizomes, a folk medicine of Shennongjia Forest District of Hubei Province. Their structures were determined as (25S)-26-O-(β-D-glucopyranosyl)-furost-1β, 3β, 22α, 26-tetrol-3-O-β-D-glucopyranosyl-(1→4)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside (1) and (25R)-26-O-(β-D-glucopyranosyl)-furost-lβ, 3β 22α, 26-tetrol 3-O-β-D-glucopyranosyl-(1→4)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside (2), on basis of chemical and spectroscopic evidences. 1 and 2 displayed marked inhibitory action towards COX-2 production in macrophages of the rat abdomen induced by LPS at 20 μg/mL.
English
Furostanol saponins with inhibitory action against COX-2 production from Tupistra chinensis rhizomes
Abstract:
Two furostanol saponins were obtained from the n-butanol fraction of methanol extract from Tupistra chinensis rhizomes, a folk medicine of Shennongjia Forest District of Hubei Province. Their structures were determined as (25S)-26-O-(β-D-glucopyranosyl)-furost-1β, 3β, 22α, 26-tetrol-3-O-β-D-glucopyranosyl-(1→4)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside (1) and (25R)-26-O-(β-D-glucopyranosyl)-furost-lβ, 3β 22α, 26-tetrol 3-O-β-D-glucopyranosyl-(1→4)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside (2), on basis of chemical and spectroscopic evidences. 1 and 2 displayed marked inhibitory action towards COX-2 production in macrophages of the rat abdomen induced by LPS at 20 μg/mL.
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Key words:
- Tupistra chinensis Bak.
- / Furostanol saponin
- / COX-2
- / Folk medicines
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