引用本文:
Xin Ming Zhou, Zhi Bing Zheng, Hong Ying Liu, Wu Zhong, Jun Hai Xiao, Li Li Wang, Song Li. Synthesis of 1-aryl-3-(3, 4-dihydro-2H-chromen-5-yl)ureas as TNF-α inhibitors[J]. Chinese Chemical Letters,
2007, 18(8): 905-908.
doi:
10.1016/j.cclet.2007.06.014
Citation: Xin Ming Zhou, Zhi Bing Zheng, Hong Ying Liu, Wu Zhong, Jun Hai Xiao, Li Li Wang, Song Li. Synthesis of 1-aryl-3-(3, 4-dihydro-2H-chromen-5-yl)ureas as TNF-α inhibitors[J]. Chinese Chemical Letters, 2007, 18(8): 905-908. doi: 10.1016/j.cclet.2007.06.014
Citation: Xin Ming Zhou, Zhi Bing Zheng, Hong Ying Liu, Wu Zhong, Jun Hai Xiao, Li Li Wang, Song Li. Synthesis of 1-aryl-3-(3, 4-dihydro-2H-chromen-5-yl)ureas as TNF-α inhibitors[J]. Chinese Chemical Letters, 2007, 18(8): 905-908. doi: 10.1016/j.cclet.2007.06.014
Synthesis of 1-aryl-3-(3, 4-dihydro-2H-chromen-5-yl)ureas as TNF-α inhibitors
摘要:
A new series of compounds, 1-aryl-3-(3, 4-dihydro-2H-chromen-5-yl) ureas, have been synthesized and their structures were confirmed by FAB-MS and 1H NMR. The preliminary pharmacological screening showed that these compounds inhibited TNF-α production in lipopolysaccharide (LPS)-stimulated THP-1 cells.
English
Synthesis of 1-aryl-3-(3, 4-dihydro-2H-chromen-5-yl)ureas as TNF-α inhibitors
Abstract:
A new series of compounds, 1-aryl-3-(3, 4-dihydro-2H-chromen-5-yl) ureas, have been synthesized and their structures were confirmed by FAB-MS and 1H NMR. The preliminary pharmacological screening showed that these compounds inhibited TNF-α production in lipopolysaccharide (LPS)-stimulated THP-1 cells.
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