Citation: Ping Xue, Xiang Hui Yan, Zheng Wang. Lipase immobilized on HOOC-MCF: A highly enantioselective catalyst for transesterification resolution of (R, S)-1-phenylethanol[J]. Chinese Chemical Letters, ;2007, 18(8): 929-932. doi: 10.1016/j.cclet.2007.06.005 shu

Lipase immobilized on HOOC-MCF: A highly enantioselective catalyst for transesterification resolution of (R, S)-1-phenylethanol

Key Laboratory of Energy Resources and Chemical Engineering, Ningxia University, Yinchuan 750021, China

Received Date: 19 March 2007

Fund Project: This work was financially supported by the National Natural Science Foundation of China (No. 50662004) and the State Key Program of Fundamental Research (No. 2004CCA05900).

Pseudomonas cepacia lipase (PSL) immobilized on the carboxyl-functionalized meso-cellular foams (HOOC-MCF) was used for the transesterification resolution of (R, S)-1-phenylethanol in organic solvent. The results showed that the ee value of (S)-1-phenylethanol and (R)-1-phenylethyl acetate reached 99% with 50% conversion of 1-phenylethanol using toluene as solvent.Furthermore, it was found that PSL/HOOC-MCF exhibited high enantioselectivity in organic solvent with log P≤2 such as toluene and hexane.
- Immobilized lipase,
- Enantioselectivity,
- Chiral resolution,
- 1-Phenylethanol
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