引用本文:
Chang Qing Shi, Zhang Qin Liu, Wen Qing Lin, Yuan Wei Chen. Synthesis and preliminary cytotoxic evaluation of substituted indoles as potential anticancer agents[J]. Chinese Chemical Letters,
2007, 18(8): 899-901.
doi:
10.1016/j.cclet.2007.05.052
Citation: Chang Qing Shi, Zhang Qin Liu, Wen Qing Lin, Yuan Wei Chen. Synthesis and preliminary cytotoxic evaluation of substituted indoles as potential anticancer agents[J]. Chinese Chemical Letters, 2007, 18(8): 899-901. doi: 10.1016/j.cclet.2007.05.052

Citation: Chang Qing Shi, Zhang Qin Liu, Wen Qing Lin, Yuan Wei Chen. Synthesis and preliminary cytotoxic evaluation of substituted indoles as potential anticancer agents[J]. Chinese Chemical Letters, 2007, 18(8): 899-901. doi: 10.1016/j.cclet.2007.05.052

Synthesis and preliminary cytotoxic evaluation of substituted indoles as potential anticancer agents
摘要:
A variety of indole derivatives were designed, synthesized and preliminarily evaluated for their in vitro cytotoxic activity in the A431 and H460 cell lines. All the compounds examined conferred unusual potency in a tumor cell cytotoxicity assay. The findings showed the indole derivatives would be a promising candidate for the development of new anticancer agents.
English
Synthesis and preliminary cytotoxic evaluation of substituted indoles as potential anticancer agents
Abstract:
A variety of indole derivatives were designed, synthesized and preliminarily evaluated for their in vitro cytotoxic activity in the A431 and H460 cell lines. All the compounds examined conferred unusual potency in a tumor cell cytotoxicity assay. The findings showed the indole derivatives would be a promising candidate for the development of new anticancer agents.
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Key words:
- Indoles
- / Synthesis
- / Kinesin spindle protein inhibitor
- / Cytotoxicity
- / Cancer treatment

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