Synthesis and preliminary cytotoxic evaluation of substituted indoles as potential anticancer agents

Chang Qing Shi Zhang Qin Liu Wen Qing Lin Yuan Wei Chen

引用本文: Chang Qing Shi,  Zhang Qin Liu,  Wen Qing Lin,  Yuan Wei Chen. Synthesis and preliminary cytotoxic evaluation of substituted indoles as potential anticancer agents[J]. Chinese Chemical Letters, 2007, 18(8): 899-901. doi: 10.1016/j.cclet.2007.05.052 shu
Citation:  Chang Qing Shi,  Zhang Qin Liu,  Wen Qing Lin,  Yuan Wei Chen. Synthesis and preliminary cytotoxic evaluation of substituted indoles as potential anticancer agents[J]. Chinese Chemical Letters, 2007, 18(8): 899-901. doi: 10.1016/j.cclet.2007.05.052 shu

Synthesis and preliminary cytotoxic evaluation of substituted indoles as potential anticancer agents

  • 基金项目:

    The authors thank the 100 Talents program of Chinese Academy of Sciences, the Chengdu Institute of Organic Chemistry, and the Graduate School of the Chinese Academy of Sciences for financial support of this work.

摘要: A variety of indole derivatives were designed, synthesized and preliminarily evaluated for their in vitro cytotoxic activity in the A431 and H460 cell lines. All the compounds examined conferred unusual potency in a tumor cell cytotoxicity assay. The findings showed the indole derivatives would be a promising candidate for the development of new anticancer agents.

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  • 收稿日期:  2007-04-09
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