Citation: Jian Jun Li, Shu Hui Jin, Xiao Mei Liang, De Kai Yuan, Dao Quan Wang. Synthesis of 12-alkoxycarbonylmethylene-1, 15-pentadecanolides[J]. Chinese Chemical Letters, ;2007, 18(8): 915-916. doi: 10.1016/j.cclet.2007.05.042 shu

Synthesis of 12-alkoxycarbonylmethylene-1, 15-pentadecanolides

Key Lab of Pesticide Chemistry and Application Technology, Department of Applied Chemistry, China Agricultural University, Beijing 100094, China

Received Date: 6 March 2007

Fund Project: We acknowledge financial support of this investigation by the National Basic Research Program of China (no. 2003CB114407).

Six novel 12-alkoxycarbonylmethylene-1, 15-pentadecanolides (3) were synthesized from 2-nitrocyclo-dodecanone by the Michael addition with acrolein followed by ring enlargement, Nef reaction and Wittig-Horner reaction. Their structures were confirmed by ¹H NMR, IR and elemental analysis. The preliminary bioassay showed that they have some fungicidal activity.
- 12-Alkoxycarbonylmethylene-1, 15-pentadecanolide,
- Macrolide,
- Acrylic ester,
- Wittig-Horner reaction,
- Fungicidal actictity
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