Citation: Qing Qing Meng, He Xiang Bai, Feng Li, Quan Rui Wang, Feng Gang Tao. A convenient synthesis of 2-aryl substituted benzo[f] [1, 2, 4]triazolo[1, 5-a]azepine derivatives[J]. Chinese Chemical Letters, ;2007, 18(7): 785-787. doi: 10.1016/j.cclet.2007.05.005 shu

A convenient synthesis of 2-aryl substituted benzo[f] [1, 2, 4]triazolo[1, 5-a]azepine derivatives

Department of Chemistry, Fudan University, Shanghai 200433, China

Received Date: 27 February 2007

Fund Project: This work was carried out with the financial assistance of the National Natural Science Foundation of China (Project 20372015).

A convenient synthetic pathway to 2-aryl-5, 6-dihydro-4H-benzo[f] [1, 2, 4]triazolo[1, 5-a]azepine derivatives 7 was developed.The synthesis was based on the cycloaddition of the 1, 2, 3, 4-tetrahydronaphthalene α-acetoxy azo compounds 3 with Ar-CN in the presence of AlCl₃ and the consecutive ring enlargement.
- Benzotriazoloazepine,
- Nitriles,
- 1, 3-Dipolar cycloaddition,
- Ring expansion
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