引用本文:
Qiu Qin He, Ke Li, Yong Bing Cao, Huan Wen Dong, Li Hua Zhao, Chao Mei Liu, Chun Quan Sheng. Design, synthesis and molecular docking studies of novel triazole antifungal compounds[J]. Chinese Chemical Letters,
2007, 18(6): 663-666.
doi:
10.1016/j.cclet.2007.04.025
Citation: Qiu Qin He, Ke Li, Yong Bing Cao, Huan Wen Dong, Li Hua Zhao, Chao Mei Liu, Chun Quan Sheng. Design, synthesis and molecular docking studies of novel triazole antifungal compounds[J]. Chinese Chemical Letters, 2007, 18(6): 663-666. doi: 10.1016/j.cclet.2007.04.025
Citation: Qiu Qin He, Ke Li, Yong Bing Cao, Huan Wen Dong, Li Hua Zhao, Chao Mei Liu, Chun Quan Sheng. Design, synthesis and molecular docking studies of novel triazole antifungal compounds[J]. Chinese Chemical Letters, 2007, 18(6): 663-666. doi: 10.1016/j.cclet.2007.04.025
Design, synthesis and molecular docking studies of novel triazole antifungal compounds
摘要:
Based on the active site of Candida albicans lanosterol 14α-demethylase (CACYP51), novel triazole compounds structurally different from the current triazole drugs were designed and synthesized.In vitro antifungal activities showed that compounds 10, 11, 16 and 20 exhibited strong activities.In addition, compounds 10, 11 and 16 also displayed certain activities against fluconazole-resistant fungi.
English
Design, synthesis and molecular docking studies of novel triazole antifungal compounds
Abstract:
Based on the active site of Candida albicans lanosterol 14α-demethylase (CACYP51), novel triazole compounds structurally different from the current triazole drugs were designed and synthesized.In vitro antifungal activities showed that compounds 10, 11, 16 and 20 exhibited strong activities.In addition, compounds 10, 11 and 16 also displayed certain activities against fluconazole-resistant fungi.
-
Key words:
- Lanosterol 14α-demethylase
- / Triazole
- / tert-Butyl
- / Antifungal activity
- / Fluconazole-resistant
扫一扫看文章
计量
- PDF下载量: 2
- 文章访问数: 596
- HTML全文浏览量: 21
下载:
