引用本文:
Cheng Jiang, Qi Dong You. An efficient and solvent-free one-pot synthesis of dihydropyrimidinones under microwave irradiation[J]. Chinese Chemical Letters,
2007, 18(6): 647-650.
doi:
10.1016/j.cclet.2007.04.002
Citation: Cheng Jiang, Qi Dong You. An efficient and solvent-free one-pot synthesis of dihydropyrimidinones under microwave irradiation[J]. Chinese Chemical Letters, 2007, 18(6): 647-650. doi: 10.1016/j.cclet.2007.04.002
Citation: Cheng Jiang, Qi Dong You. An efficient and solvent-free one-pot synthesis of dihydropyrimidinones under microwave irradiation[J]. Chinese Chemical Letters, 2007, 18(6): 647-650. doi: 10.1016/j.cclet.2007.04.002
An efficient and solvent-free one-pot synthesis of dihydropyrimidinones under microwave irradiation
摘要:
An efficient synthesis of 3, 4-dihydropyrirnidin-2(1H)-one derivatives using formic acid as catalyst, from aldehydes, β-ketoester and urea (thiourea) without solvent under the irradiation of microwave is described.Compared with the classical Biginelli reaction, this new method has the advantage of good yields (77-94% for aromatic aldehydes) and short reaction time (3-8 min).
English
An efficient and solvent-free one-pot synthesis of dihydropyrimidinones under microwave irradiation
Abstract:
An efficient synthesis of 3, 4-dihydropyrirnidin-2(1H)-one derivatives using formic acid as catalyst, from aldehydes, β-ketoester and urea (thiourea) without solvent under the irradiation of microwave is described.Compared with the classical Biginelli reaction, this new method has the advantage of good yields (77-94% for aromatic aldehydes) and short reaction time (3-8 min).
-
Key words:
- Biginelli reaction
- / 3, 4-Dihydropyrimidone
- / Microwave
- / Solvent-free
- / Formic acid
扫一扫看文章
计量
- PDF下载量: 3
- 文章访问数: 605
- HTML全文浏览量: 21
下载:
