Citation: Cheng Jiang, Qi Dong You. An efficient and solvent-free one-pot synthesis of dihydropyrimidinones under microwave irradiation[J]. Chinese Chemical Letters, ;2007, 18(6): 647-650. doi: 10.1016/j.cclet.2007.04.002 shu

An efficient and solvent-free one-pot synthesis of dihydropyrimidinones under microwave irradiation

Cheng Jiang ,
Qi Dong You

Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China

Received Date: 21 December 2006

Fund Project: This work was financially supported by a grant from "The Six Top Talents" of Jiangsu Province (no. 06-C-023) and Specialized Research Fund for the Doctoral Program of Higher Education P.R.C. (no. 20060316006).

An efficient synthesis of 3, 4-dihydropyrirnidin-2(1H)-one derivatives using formic acid as catalyst, from aldehydes, β-ketoester and urea (thiourea) without solvent under the irradiation of microwave is described.Compared with the classical Biginelli reaction, this new method has the advantage of good yields (77-94% for aromatic aldehydes) and short reaction time (3-8 min).
- Biginelli reaction,
- 3, 4-Dihydropyrimidone,
- Microwave,
- Solvent-free,
- Formic acid
1. [1]
  Qiang Cao , Xue-Feng Cheng , Jia Wang , Chang Zhou , Liu-Jun Yang , Guan Wang , Dong-Yun Chen , Jing-Hui He , Jian-Mei Lu . Graphene from microwave-initiated upcycling of waste polyethylene for electrocatalytic reduction of chloramphenicol. Chinese Chemical Letters, 2024, 35(4): 108759-. doi: 10.1016/j.cclet.2023.108759
2. [2]
  Yiyue Ding , Qiuxiang Zhang , Lei Zhang , Qilu Yao , Gang Feng , Zhang-Hui Lu . Exceptional activity of amino-modified rGO-immobilized PdAu nanoclusters for visible light-promoted dehydrogenation of formic acid. Chinese Chemical Letters, 2024, 35(7): 109593-. doi: 10.1016/j.cclet.2024.109593
3. [3]
  Hao-Nan Zhou , Lan-Yan Li , Hong-Bing Mo , Yi-Xin Li , Jun Yan , Chao Liu . Ligand-engineered octanuclear bismuth-oxo clusters with exposed active sites for enhanced CO₂-to-HCOOH electroreduction. Chinese Chemical Letters, 2025, 36(10): 111269-. doi: 10.1016/j.cclet.2025.111269
4. [4]
  Hui Zhang , Zijian Zhao , Yajing Wang , Kai Ni , Yanfei Wang , Liang Zhu , Jianyun Liu , Xiaoyu Zhao . Structurally engineered solvent-free LiFePO₄ electrodes via hot-pressing with efficient ion transport pathways for lithium extraction from brine. Acta Physico-Chimica Sinica, 2026, 42(2): 100130-0. doi: 10.1016/j.actphy.2025.100130
5. [5]
  Qinwen Zheng , Xin Liu , Lintao Tian , Yi Zhou , Libing Liao , Guocheng Lv . Mechanism of Fenton catalytic degradation of Rhodamine B induced by microwave and Fe₃O₄. Chinese Chemical Letters, 2025, 36(4): 109771-. doi: 10.1016/j.cclet.2024.109771
6. [6]
  Meiling Xu , Xinyang Li , Pengyuan Liu , Junjun Liu , Xiao Han , Guodong Chai , Shuangling Zhong , Bai Yang , Liying Cui . A novel and visible ratiometric fluorescence determination of carbaryl based on red emissive carbon dots by a solvent-free method. Chinese Chemical Letters, 2025, 36(2): 109860-. doi: 10.1016/j.cclet.2024.109860
7. [7]
  Xinyuan Li , Zhuozhu Li , Wenzhong Huang , Jiantao Li , Wei Zhang , Shihao Feng , Hao Fan , Zhuo Chen , Sungsik Lee , Congcong Cai , Liang Zhou . Solvent-free synthesis of Co single atom and nanocluster decorated N-doped carbon for efficient oxygen reduction. Chinese Chemical Letters, 2025, 36(9): 110716-. doi: 10.1016/j.cclet.2024.110716
8. [8]
  Huipeng Zhao , Xiaoqiang Du . Polyoxometalates as the redox anolyte for efficient conversion of biomass to formic acid. Chinese Journal of Structural Chemistry, 2024, 43(2): 100246-100246. doi: 10.1016/j.cjsc.2024.100246
9. [9]
  Hanqing Zhang , Xiaoxia Wang , Chen Chen , Xianfeng Yang , Chungli Dong , Yucheng Huang , Xiaoliang Zhao , Dongjiang Yang . Selective CO2-to-formic acid electrochemical conversion by modulating electronic environment of copper phthalocyanine with defective graphene. Chinese Journal of Structural Chemistry, 2023, 42(10): 100089-100089. doi: 10.1016/j.cjsc.2023.100089
10. [10]
  Di Wang , Qing-Song Chen , Yi-Ran Lin , Yun-Xin Hou , Wei Han , Juan Yang , Xin Li , Zhen-Hai Wen . Tuning strategies and electrolyzer design for Bi-based nanomaterials towards efficient CO2 reduction to formic acid. Chinese Journal of Structural Chemistry, 2024, 43(8): 100346-100346. doi: 10.1016/j.cjsc.2024.100346
11. [11]
  Zhen Liu , Zhi-Yuan Ren , Chen Yang , Xiangyi Shao , Li Chen , Xin Li . Asymmetric alkenylation reaction of benzoxazinones with diarylethylenes catalyzed by B(C₆F₅)₃/chiral phosphoric acid. Chinese Chemical Letters, 2024, 35(5): 108939-. doi: 10.1016/j.cclet.2023.108939
12. [12]
  Chunwei Lei , Jian Li , Bo Xu , Yu Xie , Yun Ling , Juhua Luo , Wei Zhang . Synthesis of Ni/MnO/C nano-microspheres with synergistic effects of dielectric and magnetic loss for efficient microwave absorption. Chinese Chemical Letters, 2025, 36(7): 110419-. doi: 10.1016/j.cclet.2024.110419
13. [13]
  Weizhong LING , Jingyi LIN , Jianglin ZHU , Yuyi LIANG , Shanshan DAI , Yu LI . Syntheses, structures, and catalytic performances of complexes with 4,4′-dihydroxy-[1,1′-biphenyl]-3,3′-dicarboxylic acid ligands. Chinese Journal of Inorganic Chemistry, 2026, 42(1): 152-160. doi: 10.11862/CJIC.20250204
14. [14]
  Jing Cao , Dezheng Zhang , Bianqing Ren , Ping Song , Weilin Xu . Mn incorporated RuO₂ nanocrystals as an efficient and stable bifunctional electrocatalyst for oxygen evolution reaction and hydrogen evolution reaction in acid and alkaline. Chinese Chemical Letters, 2024, 35(10): 109863-. doi: 10.1016/j.cclet.2024.109863
15. [15]
  Peng Wang , Daijie Deng , Suqin Wu , Li Xu . Cobalt-based deep eutectic solvent modified nitrogen-doped carbon catalyst for boosting oxygen reduction reaction in zinc-air batteries. Chinese Journal of Structural Chemistry, 2024, 43(1): 100199-100199. doi: 10.1016/j.cjsc.2023.100199
16. [16]
  Shiyu Pan , Bo Cao , Deling Yuan , Tifeng Jiao , Qingrui Zhang , Shoufeng Tang . Complexes of cupric ion and tartaric acid enhanced calcium peroxide Fenton-like reaction for metronidazole degradation. Chinese Chemical Letters, 2024, 35(7): 109185-. doi: 10.1016/j.cclet.2023.109185
17. [17]
  Nana Yang , Rui Yuan , Xinyue Fu , Xiao Tian , Jin Yu , Shengzhou Ma , Liuqing Wen , Jiabin Zhang . Concise synthesis of NDP-activated uronic acid by an oxidation reaction insertion strategy. Chinese Chemical Letters, 2025, 36(8): 110757-. doi: 10.1016/j.cclet.2024.110757
18. [18]
  Xun Zhu , Chenchen Zhang , Yingying Li , Yin Lu , Na Huang , Dawei Wang . Degradation of perfluorooctanoic acid by inductively heated Fenton-like process over the Fe₃O₄/MIL-101 composite. Chinese Chemical Letters, 2024, 35(12): 109753-. doi: 10.1016/j.cclet.2024.109753
19. [19]
  Yuanfei Liu , Wanjiao Wei , Xu Liu , Rui Hua , Yanjuan Liu , Yuefei Zhang , Wei Chen , Sheng Tang . Green and mild synthesis of Ca-MOF/COF functionalized silica microspheres in an acid-base tunable deep eutectic solvent for multi-mode chromatography. Chinese Chemical Letters, 2026, 37(1): 111186-. doi: 10.1016/j.cclet.2025.111186
20. [20]
  Xinghui Yao , Zhouyu Wang , Da-Gang Yu . Sustainable electrosynthesis: Enantioselective electrochemical Rh(III)/chiral carboxylic acid-catalyzed oxidative CH cyclization coupled with hydrogen evolution reaction. Chinese Chemical Letters, 2024, 35(9): 109916-. doi: 10.1016/j.cclet.2024.109916

Get Citation

PDF

XML

Metrics

PDF Downloads(3)
Abstract views(1282)
HTML views(37)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888

DownLoad: Full-Size Img PowerPoint

Return