引用本文:
Hong Kui Zhang, Wing Hong Chan, Albert W. M. Lee, Ping Fang Xia, Wai Yeung Wong. A novel reductive ring-opening reaction of isoxazolidine to form functionalized 1, 3-aminoalcohol[J]. Chinese Chemical Letters,
2007, 18(6): 629-632.
doi:
10.1016/j.cclet.2007.04.001
Citation: Hong Kui Zhang, Wing Hong Chan, Albert W. M. Lee, Ping Fang Xia, Wai Yeung Wong. A novel reductive ring-opening reaction of isoxazolidine to form functionalized 1, 3-aminoalcohol[J]. Chinese Chemical Letters, 2007, 18(6): 629-632. doi: 10.1016/j.cclet.2007.04.001
Citation: Hong Kui Zhang, Wing Hong Chan, Albert W. M. Lee, Ping Fang Xia, Wai Yeung Wong. A novel reductive ring-opening reaction of isoxazolidine to form functionalized 1, 3-aminoalcohol[J]. Chinese Chemical Letters, 2007, 18(6): 629-632. doi: 10.1016/j.cclet.2007.04.001
A novel reductive ring-opening reaction of isoxazolidine to form functionalized 1, 3-aminoalcohol
摘要:
Reductive cleavage of the N-O bond of isoxazolidine ring with catalytic hydrogenation over Raney nickel was described.Bicyclic isoxazolidines could be effectively converted into the corresponding 1, 3-amino-alcohol possessing a sultone or sultam moiety with high conversion and yield when the hydrogenation was catalyzed by freshly prepared Raney nickel under a pressure of 40 psi in the presence of triethylamine.
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关键词:
- Isoxazolidine
- / Hydrogenation
- / Raney nickel
- / 1, 3-Amino-alcohol
English
A novel reductive ring-opening reaction of isoxazolidine to form functionalized 1, 3-aminoalcohol
Abstract:
Reductive cleavage of the N-O bond of isoxazolidine ring with catalytic hydrogenation over Raney nickel was described.Bicyclic isoxazolidines could be effectively converted into the corresponding 1, 3-amino-alcohol possessing a sultone or sultam moiety with high conversion and yield when the hydrogenation was catalyzed by freshly prepared Raney nickel under a pressure of 40 psi in the presence of triethylamine.
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Key words:
- Isoxazolidine
- / Hydrogenation
- / Raney nickel
- / 1, 3-Amino-alcohol
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