Citation: Lei Tang, Yong Wu, Jiao Lu, Zhi Rong Zhang, Jin Cheng Yang, Li Hai. Synthesis of a novel tri-antennary galactoside with high hepatocyte targeting[J]. Chinese Chemical Letters, ;2007, 18(5): 513-515. doi: 10.1016/j.cclet.2007.03.018 shu

Synthesis of a novel tri-antennary galactoside with high hepatocyte targeting

Key Laboratory of Drug Targeting Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China

Received Date: 4 December 2006

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 30672537) and Ministry of Education of P.R. China (No. 20050610085)

A novel bifunctional compound carrying cluster thiogalactoside as the cell targeting ligands was synthesized for gene delivery to hepatocytes. Tetra-antennary dendr-OMs₄5 was used as a scaffold for the attachment of three galactosides, while the other mesylate end was linked with cholesterol through poly (ethylene glycol) chain. This design provided an effective entry for the synthesis of the bifunctional compound.
- Cluster,
- Cholesterylated galactoside,
- Targeting ligand,
- Hepatocyte-specific delivery,
- Gene delivery
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