引用本文:
Xiao Huan Zang, Cai Rui Li, Qiu Hua Wu, Chun Wang, Dan Dan Han, Zhi Wang. Combination of hollow fiber-based liquid-phase microextraction with sweeping techniques in micellar electrokinetic chromatography for the determination of Strychnos alkaloids in human urine[J]. Chinese Chemical Letters,
2007, 18(3): 316-318.
doi:
10.1016/j.cclet.2007.01.032
Citation: Xiao Huan Zang, Cai Rui Li, Qiu Hua Wu, Chun Wang, Dan Dan Han, Zhi Wang. Combination of hollow fiber-based liquid-phase microextraction with sweeping techniques in micellar electrokinetic chromatography for the determination of Strychnos alkaloids in human urine[J]. Chinese Chemical Letters, 2007, 18(3): 316-318. doi: 10.1016/j.cclet.2007.01.032
Citation: Xiao Huan Zang, Cai Rui Li, Qiu Hua Wu, Chun Wang, Dan Dan Han, Zhi Wang. Combination of hollow fiber-based liquid-phase microextraction with sweeping techniques in micellar electrokinetic chromatography for the determination of Strychnos alkaloids in human urine[J]. Chinese Chemical Letters, 2007, 18(3): 316-318. doi: 10.1016/j.cclet.2007.01.032
Combination of hollow fiber-based liquid-phase microextraction with sweeping techniques in micellar electrokinetic chromatography for the determination of Strychnos alkaloids in human urine
摘要:
A new method for the enrichment of Strychnos alkaloids in biological samples via liquid-phase rnicroextraction (LPME) based on porous polypropylene hollow fibers in combination with on-line sweeping in micellar electrokinetic chromatography was developed. The calibration curve was linear over the range of 20-200 ng mL-1 for both strychnine and brucine in human urine sample. The detection limits (S/N=3:1) for strychnine and brucine were 1 ng mL-1 and 2 ng mL-1, respectively. The LPME-sweeping method has been successfully applied to the analysis of strychnine and brucine in real urine samples.
English
Combination of hollow fiber-based liquid-phase microextraction with sweeping techniques in micellar electrokinetic chromatography for the determination of Strychnos alkaloids in human urine
Abstract:
A new method for the enrichment of Strychnos alkaloids in biological samples via liquid-phase rnicroextraction (LPME) based on porous polypropylene hollow fibers in combination with on-line sweeping in micellar electrokinetic chromatography was developed. The calibration curve was linear over the range of 20-200 ng mL-1 for both strychnine and brucine in human urine sample. The detection limits (S/N=3:1) for strychnine and brucine were 1 ng mL-1 and 2 ng mL-1, respectively. The LPME-sweeping method has been successfully applied to the analysis of strychnine and brucine in real urine samples.
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Key words:
- Hollow fiber-based liquid-phase microextraction
- / Sweeping
- / MEKC
- / Strychnos alkaloids
- / Urine
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