Citation: Shou Wen Jin, Bin Liu, Wan Zhi Chen. Pd(OAc)₂ catalyzed synthesis of heteroaryl-substituted 1,8-naphthyridine derivatives via C-N-coupling reactions of chloronaphthyridines[J]. Chinese Chemical Letters, ;2007, 18(4): 383-386. doi: 10.1016/j.cclet.2007.01.024 shu

Pd(OAc)₂ catalyzed synthesis of heteroaryl-substituted 1,8-naphthyridine derivatives via C-N-coupling reactions of chloronaphthyridines

Department of Chemistry, Zhejiang University, Xixi Campus, Hangzhou 310028, China

Received Date: 10 October 2006

Fund Project: The project was supported by the National Natural Science Foundation of China (no. 20572096) and the Zhejiang Provincial Science Foundation (Grant R405066).

An efficient route to synthesize the heteroaryl-substituted 1,8-naphthyridine derivatives was described. Eight 2-heteroaryl-and 2,7-diheteroaryl-l,8-naphthyridine derivatives were obtained through palladium-catalyzed C-N-coupling reactions of chloronaphthyridines with imidazole, benzimidazole, morpholine, 3,5-dimethylpyrazole, and phthalimide in moderate to good yields.
- Palladium,
- Naphthyridine,
- C-N-coupling reaction,
- Catalyst
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