Citation: Yong Deng, Da Cheng Yang, Yi Shen, Yu Guo Zhong. Synthesis and antiangiogenic activities of 5-amino-1,3-dihydro-1,3-dioxo-2H-isoindole-2-propanoic acid derivatives[J]. Chinese Chemical Letters, ;2007, 18(1): 7-9. doi: 10.1016/j.cclet.2006.11.031 shu

Synthesis and antiangiogenic activities of 5-amino-1,3-dihydro-1,3-dioxo-2H-isoindole-2-propanoic acid derivatives

a Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China;
b School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China

Received Date: 13 June 2006

Based on the structure-activity relationships and antiangiogenic mechanism of RGD-containing peptides, a series of 5-amino-1,3-dihydro-1,3-dioxo-2H-isoindole derivatives were synthesized. The structures were characterized by ¹H NMR, MS and elementary analysis. There ability to inhibit angiogenesis were evaluated by chick embryo chorioallantoic membrane assay at 10^-5 mol/L. Compounds 7a and 7b displayed obvious antiangiogenic activity.
- RGD peptide sequence,
- Integrin α_vβ₃,
- 5-Amino-1,3-dihydro-1,3-dioxo-2H-isoindole derivatives,
- Synthesis,
- Antiangiogenic activity
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