Citation: Chao Feng Zhang, Li Fan, Pin Yang. Study of the interaction of Zn²⁺ with Aβ(10-21) by fluorescamine assay[J]. Chinese Chemical Letters, ;2007, 18(1): 97-98. doi: 10.1016/j.cclet.2006.11.016 shu

Study of the interaction of Zn²⁺ with Aβ(10-21) by fluorescamine assay

Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China

Received Date: 12 May 2006

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 30470408).

Zinc may play a role as a co-factor in the pathogenesis of Alzheimer's disease (AD) through influencing the conformation and neurotoxicity of amyloid β-protein (Aβ). Using the fluorescamine assay, we show for the first time that Zn²⁺induced Aβ(10-21) aggregate in a concentration-dependent manner. These results indicate that Aβ(10-21) can be used as an in vitro model in Zn²⁺-induced Aβ aggregation and that the region 10-21 to be the minimal fragment of zinc-binding domain of full length Aβ(1-42).
- Aβ(10-21),
- Fluorescamine,
- Zn²⁺,
- Aggregation
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