Citation: Zhen Hu, Wen Chao Guan, Xiang Ying Tang, Li Zhen Huang, Hong Xu. Synthesis of water-soluble cystine C₆₀ derivative with catalyst and its active oxygen radical scavenging ability[J]. Chinese Chemical Letters, ;2007, 18(1): 51-54. doi: 10.1016/j.cclet.2006.11.013 shu

Synthesis of water-soluble cystine C₆₀ derivative with catalyst and its active oxygen radical scavenging ability

Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, China

Received Date: 28 April 2006

Fund Project: The project supported by the National Natural Science Foundation of China (No. 20474020).

A novel water-soluble cystine C₆₀ derivative was synthesized in the presence of the catalyst, tetrabutylammonium hydroxide (TBAH). The product was characterized by FT-IR, UV, ¹H NMR, ¹³C NMR, MS and elemental analysis. Furthermore, the scavenging ability to superoxygen anion radical O₂^·- and hydroxyl radical ^·OH was studied by chemiluminescence.It was found that cystine C₆₀ derivative showed an excellent efficiency in eliminating superoxygen anion radical and hydroxyl radical. The 50%inhibition concentration (IC₅₀) for superoxygen anion radical and hydroxyl radical were 0.167 and 0.008 mg/mL, respectively.
- Cystine C₆₀derivatives,
- TBAH,
- Superoxygen anion radical,
- Hydroxyl radical,
- Chemiluminescence
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