Citation: Xingtian Huang, Zhipeng Li, Dongyang Wang, Yiqun Li. Bovine serum albumin: An efficient and green biocatalyst for the one-pot four-component synthesis of pyrano[2,3-c]pyrazoles[J]. Chinese Journal of Catalysis, ;2016, 37(9): 1461-1468. doi: 10.1016/S1872-2067(15)61088-9 shu

Bovine serum albumin: An efficient and green biocatalyst for the one-pot four-component synthesis of pyrano[2,3-c]pyrazoles

a. College of Life Science and Technology, Jinan University, Guangzhou 510632, Guangdong, China;
b. Department of Chemistry, Jinan University, Guangzhou 510632, Guangdong, China

Received Date: 6 March 2016
Revised Date: 24 March 2016

Fund Project: This work was supported by the National Natural Science Foundation of China(21372099, 21072077), and the the Natural Science Foundation of Guangdong Province(10151063201000051, 8151063201000016).

The use of biocatalysts is attracting an increasing amount of attention in chemical catalysis. Here, we have shown that bovine serum albumin(BSA), a ubiquitous, inexpensive, non-enzymatic transport protein, can serve as an efficient, retrievable catalyst in the one-pot four-component reaction of aryl aldehydes, malononitrile, hydrazine hydrate, and ethyl acetoacetate for the synthesis of pyrano[2,3-c]pyrazoles under mild reaction conditions. The BSA biocatalyst also displayed a high catalytic affinity for acyclic/cyclic ketones to yield the corresponding pyrano[2,3-c]pyrazoles or their spirocyclic variants. The BSA could be used for at least five cycles without serious loss of catalytic activity. This novel, efficient protocol has the merits of high yield, operational simplicity, and a relatively benign environmental impact. Moreover, the method extends the promiscuity of BSA as a biocatalyst.
- Bovine serum albumin,
- Biocatalyst,
- Multicomponent reaction,
- Pyrano[2,3-c]pyrazole,
- Biocatalytic promiscuity
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