Citation: Dan Dang, Ze Wang, Weigang Lin, Wenli Song. Synthesis of anisole by vapor phase methylation of phenol with methanol over catalysts supported on activated alumina[J]. Chinese Journal of Catalysis, ;2016, 37(5): 720-726. doi: 10.1016/S1872-2067(15)61074-9 shu

Synthesis of anisole by vapor phase methylation of phenol with methanol over catalysts supported on activated alumina

1.
State Key Laboratory of Multi-Phase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China

Corresponding author: Ze Wang,
Received Date: 19 February 2016
Available Online: 25 February 2016
Fund Project: 国家自然科学基金(51476180) (51476180)国家重点基础研究发展计划(973计划,2014CB744304). (973计划,2014CB744304)

The synthesis of anisole by vapor phase methylation of phenol with methanol over activated alumina (AA) supported catalysts was investigated in a fixed bed reactor. KH₂PO₄/AA gave the best performance among the eight tested catalysts. The catalyst was prepared by loading KH₂PO₄ on AA and then calcining at the optimized temperature of 700 ℃ for 8 h. In the vapor phase reaction, the level of anisole yield (LAY) has a maximum at 400-450 ℃ when the temperature varied from 300 to 500 ℃, which decreased slightly with increasing WHSV and increased distinctly with increasing mole fraction of methanol. On comparing O-methylation and C-methylation of phenol, a low temperature, high WHSV (short residence time), and a low methanol concentration over the KH₂PO₄/AA catalyst with higher K contents were found to increase anisole selectivity by O-methylation of phenol. The reaction routes to the major products and the catalytic mechanism were suggested, and a ‘K-acid' bifunctional process may be a critical factor to the formation of anisole.
- Phenol,
- Methanol,
- Catalysis,
- Anisole,
- Methylation
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沈阳化工大学材料科学与工程学院沈阳 110142