2002 Volume 13 Issue 3

The Reactions of 3,7-Dinitrodibenzobromolium Salt with Some Amines
Zi Jie HOU , Xian Hua PAN , Ling HE
2002, 13(3): 189-192
[Abstract](191) [FullText HTML] [PDF 1260KB](1)
The reactions of 3,7-dinitrodibenzobromolium salt with some amines were studied. A reaction mechanism based on the structure of the major product 6 and the minor product 7 was proposed. The reaction was considered to proceed via a substituted benzyene intermediate.
Solid Phase Synthesis of 4(1H)Quinolones from Resin-Bound Cyclic Malonic Ester
Zhan Xiang LIU , Wan Li CHEN , Xian HUANG
2002, 13(3): 193-194
[Abstract](281) [FullText HTML] [PDF 603KB](0)
The solid phase synthesis of 4 (1H) quinolones has been reported.
A New Method for Synthesis of Methyl 3-Azido-3-deoxy-2-O-mesyl-5-O-benzoylxylofuranoside
Zi Cheng LI , Ning JIANG , Shu Hua CHEN , Ding LU
2002, 13(3): 195-198
[Abstract](161) [FullText HTML] [PDF 1467KB](0)
A new method for synthesis of 3-azido-3-deoxyxylofuranoside was described. D-ribose was methylated, then treated with methanesulfonyl chloride to give Ⅱ. Ⅱ was selectively replaced by benzoate at the 5-position to give Ⅲ. All these processes gave good yields. Ⅲ was treated with sodium azide to afford Ⅳ, whose structure was determined by 1H NMR and 13C NMR.
Concise and Efficient Synthesis of Dehydropeptide Analogues from Unsaturated 5(4H)-Oxazolone
Ming Tao LIANG , De Xin WANG
2002, 13(3): 199-200
[Abstract](265) [FullText HTML] [PDF 697KB](1)
Some dehydropeptide analogues were directly synthesized by the reaction of unsaturated oxazolones with free amino acids.
Synthesis of Cytotoxic Sinapyl Alcohol Derivatives from Ligularia nelumbifolia
Yu ZHAO , Wei LU , Xiao Jiang HAO , Jun Chao CAI , Hong YU , Thierry SEVENET , FranÇise GUÉITTE
2002, 13(3): 201-204
[Abstract](180) [FullText HTML] [PDF 1360KB](3)
Total synthesis of two cytotoxic natural products, nelumol A (1) and nelumal A (2), were carried out by two different paths. 4-O-Benzyl substitute analogues 26 and 27, as well as the 4-O-(2-methyl-butenyl) derivatives 29 and 30 were also synthesized for a SAR investigation. 1 and 2 were also measured on different tumor cell line.
An Interesting Approach to Bis-calix[5]arene Analogue from Calix[6]arene
Hai Bing LI , Yuan Yin CHEN , Shu Ling GONG
2002, 13(3): 205-206
[Abstract](194) [FullText HTML] [PDF 783KB](0)
By 1,4-bridging of p-tert-butylcalix [6] arene with 2,6-bis (bromomethyl)-4-methyl-anisole, a new type of bis-calix [5] arene analogue was obtained in high yield..
On the Mechanism of Condensation between 5-Amino-4, 6-dichloro-2-methylpyrimidine and 1-Acetyl-2-imidazolin-2-one
Bin SU , Hui LI , Meng Shen CAI , Zhong Jun LI
2002, 13(3): 207-210
[Abstract](264) [FullText HTML] [PDF 1111KB](0)
The condensation reaction between 5-amino-4, 6-dichloro-2-methylpyrimidine and 1-acetyl-2-imidazolin-2-one using POCl3 as solvent gave 4, 6-dichloro-2-methyl-5-(l-acetyl-tetrahydro-imidazo-2-ylidene)-aminopyrimidine predominantly and 4, 6-dichloro-2-methyl-5-{1-[ l-(2-oxo-tetrahydro-imidazolyl)]-acetyene}-aminopyrimidine as by-product. No 4, 6-dichloro-2-methyl-5-(1-acetyl-2-imidazolin-2-yl)-aminopyrimidine was found. The result indicated an esterifi-cation-addition-elimination mechanism.
High Activity and Selectivity of Cu/SiO2 Catalyst for the Direct Synthesis of Indole
Lei SHI , Jun Ming SUN , Xin Ping WANG , Xan Yun SU , Tian Xi CAI
2002, 13(3): 211-212
[Abstract](185) [FullText HTML] [PDF 732KB](0)
Copper supported over silica exhibited very high activity and selectivity for the direct synthesis of indole at atmospheric pressure. Under the reaction temperature of 325℃,the yield of indole could obtain 88%.
Antitumour Activity of Chitosan Hydrogen Selenites
Cai Qin QIN , Ling XIAO , Yu Min DU , Xiao Hai GAO
2002, 13(3): 213-214
[Abstract](269) [FullText HTML] [PDF 762KB](0)
Chitosans reacted with selenious acid to prepare chitosan hydrogen selenites, which were found to be growth-inhibitory against sarcoma 180 solid tumor. The results indicated that the activity also depended on the molecular weight of chitosan supports.
Preparation of Europium Induced Conformation-specific anti-calmodulin Monoclonal Antibody
Wei Guo LI , Chao QI , Li DU , Zi LIU , Da Qing ZHAO , Jia Zuan NI
2002, 13(3): 215-216
[Abstract](169) [FullText HTML] [PDF 710KB](0)
Monoclonal antibody technique was employed to detect the conformational difference of CaM induced by metal ions. A trivalent europium ion induced conformation-specific anti-calmodulin monoclonal antibody was successfully prepared with europium-saturated calmodulin as antigen.
Synthesis of Well-Defined Dendritic-Linear Diblock and Triblock Copolymers by Controlled Free Radical Polymerization
You Liang ZHAO , Chuan Fu CHEN , Fu XI
2002, 13(3): 217-218
[Abstract](166) [FullText HTML] [PDF 801KB](0)
The design and synthesis of novel dendritic-linear block copolymers were described. The copolymers were synthesized by atom transfer radical polymerization (ATRP) using dendritic polyarylether 2-bromoisobutyrate macroinitiator. ATRP carried out in bulk with CuBr/bipy catalyst at 120℃, yielded well-defined block copolymers with polydispersities less than 1.36.
Preparation of Polystyrenylphosphonous Acid of Low Polymerization Degree and Influence of Initiators upon the Free Radical Reaction Mechanism
Xiang Kai FU , Yan SUI , Li CHEN
2002, 13(3): 219-222
[Abstract](175) [FullText HTML] [PDF 1457KB](0)
The polystyrenylphosphonous acid (PSPA) of low polymerization degree was prepared with one step reaction. The reaction mechanism was changed with different initiators. For the reaction with AIBN or BPO as the initiator, there are 2 or 3 series of radical reaction chains and 5 or 9 series of polystyrenyl products. The main products are PSPA without or with the fragment of the initiator H[CH(C6H5)-CH2]n-PO2H2 and C6H5CO2-[CH2CH (C6H5)]n-PO2H2 respectively.
Interaction between Bifunctional Dioxo Macrocyclic Polyamine Co(Ⅱ) Complex and DNA in Metallomicellar System
Qing Xiang XIANG , Hong ZHOU , Xin Yan WANG , Xiao Qi YU , Jing Ku BAO , Ru Gang XIE
2002, 13(3): 223-226
[Abstract](174) [FullText HTML] [PDF 1549KB](0)
The cleavage of DNA (pUC18) by lipophilic macrocyclic polyamine Co(Ⅱ) complex was investigated in metallomicellar system. The results showed that the conversion of plasmid DNA (pUC18) increases with the increase of the concentration of complex under physiological conditions.
DSC and NMR Study on the Inclusion Complex of Lappaconitine with β-Cyclodextrin
Kai Jun LIAO , Xiao Hua YAN , Dong Yun ZHAO , Xue Yi MA
2002, 13(3): 227-230
[Abstract](254) [FullText HTML] [PDF 1184KB](0)
The inclusion complex of lappaconitine (Lap) with β-cyclodextrin (β-CD) has been studied by the differential scanning calorimetry (DSC) and 1H-NMR, 2D-NMR spectroscopy.The structure of the complex has been deduced.
A New Bibenzyl Derivative from Bletilla striata
Guang Xuan HAN , Li Xin WANG , Zheng Bing GU , Wei Dong ZHANG , Hai Sheng CHEN
2002, 13(3): 231-232
[Abstract](162) [FullText HTML] [PDF 574KB](0)
A new compound was isolated from Bletilla striata. Its structure was elucidated as 5-hydroxy-4-(p-hydroxybenzyl)-3', 3-dimethoxybibenzyl by spectroscopic method.
Norditerpenoid Alkaloids from the Roots of Aconitum hemsleyanum Pritz. var. Pengzhouense
Chong Sheng PENG , Feng Peng WANG , Xi Xian JIAN
2002, 13(3): 233-236
[Abstract](174) [FullText HTML] [PDF 1504KB](1)
In continuation of our studies on Aconitum hemsleyanum Pritz. var. pengzhouense, two new norditerpenoid alkaloids, pengshenines A (1) and B (2), have been isolated from the roots of the plants and their structures were elucidated by 1D-and 2D-NMR.
Two New Phenolic Glycosides from the Roots of Rhododendron molle
Guan Hu BAO , Li Quan WANG , Kin Fai CHENG , Guo Wei QIN
2002, 13(3): 237-240
[Abstract](174) [FullText HTML] [PDF 1343KB](0)
Two new phenolic glycosides, everninic acid methyl ester-2-O-β-D-xylopyran-osyl-(16)-β-D-glucopyranoside 1 and 7-hydroxy-5-methoxyphthalide-7-β-D-xylopyranosyl-(1→6)-β-D-glucopyranoside 2 were isolated from the roots of Rhododendron molle G. Don. Their structures were determined by spectral evidence including 2D NMR techniques.
A New Furostanol Saponin from Dioscorea futshauensis
Hong Wei LIU , Ge Xia QU , Xin Sheng YAO
2002, 13(3): 241-244
[Abstract](165) [FullText HTML] [PDF 1187KB](0)
A new furostanol saponin presenting moderate bioactivity of inducing morphological deformation of Pyricularia oryzae mycelia was isolated from Dioscorea futshauensis R.Kunth by bioactivity-guided fractionation. The structure was established as 26-O-β-D-glucopyranosyl-3β, 26-diol-23(S)-methoxyl-(25R)-furost-5,20 (22)-diene-3-O-[α-L-rhamnopyranosyl (1→2)-b-D-glucopyranosyl (1→3)]-β-D-glucopyranoside on the basis of chemical evidencesand spectral analysis, especially by 2D-NMR techniques.
A New Phytosterone from Cyanotis arachnoidea
Cheng Yu TAN , Jin Hui WANG , Wan XIAO , Xian LI
2002, 13(3): 245-246
[Abstract](240) [FullText HTML] [PDF 621KB](0)
A new phytosterone named cyanosterone B (1) has been isolated from Cyanotis arachnoidea C. B. Clarke. The structure of cyanosterone B was elucidated as 3β, 5β, 14α, 20R, 22R-pentahydroxy-cholest-7-en-6-one on the basis of spectroscopic analysis.
Sesquiterpene lactone glycosides from Carpesium macrocephalum
Chao YANG , Yan Ping SHI , Xing WANG , Zhong Jian JIA
2002, 13(3): 247-248
[Abstract](157) [FullText HTML] [PDF 686KB](2)
Two new sesquiterpene lactone glycosides were isolated from the seeds of Carpesium macrocephalum. Their structures were elucidated as 2α-O-β-D-glucopyranosy-5α, 11αH-eudesma-4 (15)-en-12, 8β-olide and 2α-O-β-D-glucopyranosy-5αH-eudesma-4(15), 11 (13)-dien-12, 8β-olide by spectral methods (HRMS, ID and 2D NMR).
A New Bisesquiterpene from Ligularia macrophylla
Bo FU , Qi Xiu ZHU , Xiu Ping YANG , Zhong Jian JIA
2002, 13(3): 249-250
[Abstract](170) [FullText HTML] [PDF 683KB](0)
From the roots of Ligularia macrophylla,a bisesquiterpene,ligumacrophyllal was isolated and its structure was elucidated on the basis of spectroscopic methods.
Monepaloside K, a New Triterpenoid Saponin from Morina nepalensis var. alba Hand.-Mazz.
Rong Wei TENG , De Zu WANG , Chong Ren YANG
2002, 13(3): 251-252
[Abstract](166) [FullText HTML] [PDF 766KB](0)
One new triterpenoid saponin, monepaloside K (1) was isolated from the water-soluble part of the whole plant of a famous Tibetan medicinal herb, morina nepalensis var. alba Hand.-Mazz.. Its structure was determined to be 3-O-α-L-arabinopyranosyl-(1→3)-β-D-xylopyranosyl siaresinolic acid on the basis of spectroscopic evidences, especially 2D NMR techniques.
Two New Triterpenoid Glycosides from Elsholtzia bodinieri Van't
Wei Ming ZHU , Hong Ping HE , Song WANG , Guo Ying ZUO , Xiao Jiang HAO
2002, 13(3): 253-255
[Abstract](169) [FullText HTML] [PDF 897KB](0)
Two new triterpenoid glycosides, hederagenin-3-O-β-D-xylopyranoside (1), dodecandral 3-O-β-D-xylopyranoside(2), were isolated from Elsholtzia bodinieri Van't. The structures of 1 and 2 were established by spectroscopic and chemical methods.
Novel Blue Light-emitting PPV-based Copolymer Containing Triazole and Carbazole Units
Ze LIU , Li Xiang WANG , Xia Bin JING , Fo Song WANG
2002, 13(3): 256-257
[Abstract](170) [FullText HTML] [PDF 757KB](0)
A novel alternating conjugated copolymer containing triazole and carbazole units was synthesized by the Wittig reaction. The resulting bipolar conjugated polymer emits a pure light with good thermal stability, which is a promising candidate for polymer light emitting display.
Aggregation of Sodium Dodecyl Sulfonate in Poly-ethylene Glycol Aqueous Solutions Studied by Two-dimensional Nuclear Overhauser Enhancement Spectroscopy
Xiao Wen FANG , Hong Chang GAO , Shi Zhen MAO , Sui ZHAO , Jia Yong YU , You Ru DU
2002, 13(3): 258-261
[Abstract](258) [FullText HTML] [PDF 1435KB](0)
Two-dimensional nuclear overhauser enhancement (2D NOESY) measurements show that sodium dodecyl sulfonate SDSN molecules co-aggregate with poly-ethylene glycol PEG in their aqueous solution at a concentration range of SDSN between the so-called co-aggregation concentration (cac) and the normal critical micellar concentration (cmc). SDSN micelles are formed when the cmc of SDSN is reached with PEG uniformly distributed in the interior.
Aggregation of the Adsorbed Proteins-in Solution or on the Surface?
Tong Wen XU
2002, 13(3): 262-265
[Abstract](157) [FullText HTML] [PDF 1409KB](0)
The adsorption of bovine serum albumin (BSA) on porous polyethylene (PE) membrane was studied based on adsorption and desorption measurements as well as FTIR analysis. A different mechanism was proposed which showed that a critical concentration existed in the adsorptional process. Below this concentration, the adsorption seems to be conducted in a normal side-on way; above this concentration, the adsorption is in an aggregation way.
Study on the Surface Photovoltage and Fluorescence Properties of N, N'-Bis(4'-aminopheny)-1, 4 quinonenediimine Doped with H4SiW12O40
Jian GONG , Ji Hua YANG , Xiu Jun CUI , Zhong Min SU , Lun Yu QU
2002, 13(3): 266-268
[Abstract](249) [FullText HTML] [PDF 994KB](0)
Aniline oligomer composite materials using heteropolyacid H4SiW12O40 as dopant was synthesized, and the effect of the doping concentration on the photoluminescence and surface photovoltaic properties were investigated.
Optimized Separation of Pharmacologically Active Xanthones from Securidaca inappendiculata by Capillary Electrophoresis
Tao BO , Xue Dong YANG , Fei GAO , Ke An LI , Hu Wei LIU , Li Zhen XIU
2002, 13(3): 269-272
[Abstract](267) [FullText HTML] [PDF 1361KB](0)
A capillary electrophoresis (CE) method has been firstly used for the separation of the therapeutically important xanthones from Securidaca inappendiculata. The separation of the nine xanthones was systematically optimized with respect to pH, concentration of running buffers, addition of sulfated β-CD, applied voltage and column temperature. Baseline separation was achieved for the nine xanthones in less than 15 minutes using a background electrolyte consisting of 200 mmol/L borate (pH 9.5) and 10 mmol/L sulfated β-CD.
A Novel Micro-hole Electrode Used to Investigate Electron Transfer Reactions at ITIES
Dong Ping ZHAN , Bing Liang WU
2002, 13(3): 273-276
[Abstract](169) [FullText HTML] [PDF 1378KB](0)
A novel micro-hole electrode was fabricated to investigate the electron transfer reaction at the interface between two immiscible electrolyte solutions (ITIES). The electron transfer reaction between ferro/ferricyanide in aqueous phase (W) and ferrocene in 1, 2-dichloroethane (O) phase was studied as a test experiment. The results showed that the diffusion coefficient obtained from the micro-hole electrode was consistent with that obtained at macro-interface. Due to its simplicity and the very small IR drop it will be a useful tool for the study of ITIES systems.
Modulation of Electrochemical Oscillations by Specific Adsorption of Cl-during the Electrooxidation of Methanol on Pt Electrode
Ze Lin LI , Ji Hua HUANG , Xiao Ming XIAO , Yue ZENG , Xia CHU
2002, 13(3): 277-278
[Abstract](165) [FullText HTML] [PDF 830KB](0)
Potential oscillation during the electrocatalytic oxidation of methanol can be modulated by the specific adsorption of Cl- on the platinum electrode, which suppresses the electrocatalytic oxidation of methanol, and makes the cross cycle in the cyclic voltammogram become smaller and finally disappear with the increase of Cl- concentration. The method is also applicable to the electrocatalytic oxidation of other small organic molecules.
Study on Mg/Fe Mixed Oxides Derived from Hydrotalcite as De-SOx Catalyst
Guang Lan ZHUO , Yin Fei CHEN , Zhong Hua GE , Xuan Zhen JIANG
2002, 13(3): 279-282
[Abstract](289) [FullText HTML] [PDF 1609KB](0)
A novel class of desulfurization agent derived from hydrotalcite has been developed and its activity for Sox uptake have been investigated. The results showed that the Mg/Fe mixed oxide having high Sox uptake ability at a broad reaction temperature (e.g. 673K~973K). The Mg/Fe ratio of the mixed oxide strongly affect the desulfurization role of the material and it can be used repeatly without much loss of Sox uptake ability.
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