Three minor new compounds from the aerial parts of Leonurus japonicus

Wei-Mao Zhong Zhao-Meng Cui Zhi-Ke Liu Yan Yang Da-Rong Wu Shao-Hua Liu Hui Long Han-Dong Sun Yong-Jun Dang Wei-Lie Xiao

Citation:  Wei-Mao Zhong, Zhao-Meng Cui, Zhi-Ke Liu, Yan Yang, Da-Rong Wu, Shao-Hua Liu, Hui Long, Han-Dong Sun, Yong-Jun Dang, Wei-Lie Xiao. Three minor new compounds from the aerial parts of Leonurus japonicus[J]. Chinese Chemical Letters, 2015, 26(8): 1000-1003. doi: 10.1016/j.cclet.2015.05.004 shu

Three minor new compounds from the aerial parts of Leonurus japonicus

    通讯作者: Yong-Jun Dang,
    Wei-Lie Xiao,
  • 基金项目:

    Technology Support Program of China (No. 2013BAI11B02) (No. 2013BAI11B02)

    the Natural Science Foundation of Yunnan Province (No. 2012FB178)  (No. 2012FB178)

摘要: Phytochemical investigation of the aerial parts of Leonurus japonicus led to the isolation of one new labdane diterpenoid, leojaponin D (1) and two new ionone derivatives, leojaponones A and B (2 and 3), together with seven known diterpenoids (4-10). Their structures were elucidated by extensive 1D and 2D NMR spectroscopic data and by comparison with data reported in the literature. Selected isolates were evaluated their effects on Jurkat IL2 secretion.

English

  • 
    1. [1] The Editorial Board of Flora of China, Flora of China, Science Press, Beijing, 1977, pp. 505-511.[1] The Editorial Board of Flora of China, Flora of China, Science Press, Beijing, 1977, pp. 505-511.

    2. [2] S.Y. Hu, A contribution to our knowledge of Leonurus L., I-mu-ts'ao, the Chinese motherwort, Am. J. Chin. Med. 4 (1976) 219-237.[2] S.Y. Hu, A contribution to our knowledge of Leonurus L., I-mu-ts'ao, the Chinese motherwort, Am. J. Chin. Med. 4 (1976) 219-237.

    3. [3] L.H. Shen, S.L. Wang, Research progress on Leonurus Heterophyllus Sweet, Med. Plant. 1 (2010) 48-51.[3] L.H. Shen, S.L. Wang, Research progress on Leonurus Heterophyllus Sweet, Med. Plant. 1 (2010) 48-51.

    4. [4] Z.K. Liu, D.R. Wu, Y.M. Shi, et al., Three new diterpenoids from Leonurus japonicus, Chin. Chem. Lett. 25 (2014) 677-679.[4] Z.K. Liu, D.R. Wu, Y.M. Shi, et al., Three new diterpenoids from Leonurus japonicus, Chin. Chem. Lett. 25 (2014) 677-679.

    5. [5] P.M. Giang, P.T. Son, K. Matsunami, H. Otsuka, New labdane-type diterpenoids from Leonurus heterophyllus Sw, Chem. Pharm. Bull. 53 (2005) 938-941.[5] P.M. Giang, P.T. Son, K. Matsunami, H. Otsuka, New labdane-type diterpenoids from Leonurus heterophyllus Sw, Chem. Pharm. Bull. 53 (2005) 938-941.

    6. [6] A.A. Hussein, M.J.J. Meyer, B. Rodríguez, Complete 1H and 13C NMR assignments of three labdane diterpenoids isolated from Leonotis ocymifolia and six other related compounds, Magn. Reson. Chem. 41 (2003) 147-151.[6] A.A. Hussein, M.J.J. Meyer, B. Rodríguez, Complete 1H and 13C NMR assignments of three labdane diterpenoids isolated from Leonotis ocymifolia and six other related compounds, Magn. Reson. Chem. 41 (2003) 147-151.

    7. [7] P.M. Hon, E.S. Wang, S.K.M. Lam, et al., Preleoheterin and leoheterin, two labdane diterpenes from Leonurus heterophyllus, Phytochemistry 33 (1993) 639-641.[7] P.M. Hon, E.S. Wang, S.K.M. Lam, et al., Preleoheterin and leoheterin, two labdane diterpenes from Leonurus heterophyllus, Phytochemistry 33 (1993) 639-641.

    8. [8] H.Q. Gong, R. Wang, Y.P. Shi, New labdane-type diterpenoids from Leonurus heterophyllus, Helv. Chim. Acta 95 (2012) 618-625.[8] H.Q. Gong, R. Wang, Y.P. Shi, New labdane-type diterpenoids from Leonurus heterophyllus, Helv. Chim. Acta 95 (2012) 618-625.

    9. [9] A.H. Zhao, R.T. Li, B. Jiang, et al., Three new compounds from Isodon melissoides, J. Asian Nat. Prod. Res. 7 (2005) 151-156.[9] A.H. Zhao, R.T. Li, B. Jiang, et al., Three new compounds from Isodon melissoides, J. Asian Nat. Prod. Res. 7 (2005) 151-156.

    10. [10] J. Shitamoto, K. Matsunami, H. Otsuka, T. Shinzato, Y. Takeda, Crotlionsides A-C, three new megastigmane glucosides, two new pterocarpan glucosides and a chalcone C-glucoside from the whole plants of Crotalaria zanzibarica, Chem. Phar. Bull. 58 (2010) 1026-1032.[10] J. Shitamoto, K. Matsunami, H. Otsuka, T. Shinzato, Y. Takeda, Crotlionsides A-C, three new megastigmane glucosides, two new pterocarpan glucosides and a chalcone C-glucoside from the whole plants of Crotalaria zanzibarica, Chem. Phar. Bull. 58 (2010) 1026-1032.

    11. [11] S.P. Ding, J.C. Li, J. Xu, L.G. Mao, Study on the mechanism of regulation on peritoneal lymphatic stomata with Chinese herbal medicine, World J. Gastroenterol. 8 (2002) 188-192.[11] S.P. Ding, J.C. Li, J. Xu, L.G. Mao, Study on the mechanism of regulation on peritoneal lymphatic stomata with Chinese herbal medicine, World J. Gastroenterol. 8 (2002) 188-192.

    12. [12] Y.R. Ren, F. Pan, S. Parvez, et al., Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes, PLoS ONE 12 (2008) e4009.[12] Y.R. Ren, F. Pan, S. Parvez, et al., Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes, PLoS ONE 12 (2008) e4009.

  • 加载中
计量
  • PDF下载量:  0
  • 文章访问数:  1476
  • HTML全文浏览量:  26
文章相关
  • 发布日期:  2015-05-11
  • 收稿日期:  2015-01-25
  • 网络出版日期:  2015-04-15
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

/

返回文章