English

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• 1. [1] (a) R. Filler, Y. Kobayashi, L.M. Yagupolskii, Organofluorine Compounds in Medicinal Chemistry and Biomedical Applications, Elsevier, Amsterdam, 1993; (b) R.E. Banks, B.E. Smart, C.J. Tatlow, Organofluorine Chemistry: Principles and Comercial Applications, Springer, New York, 1994, pp. 237-262; (c) T. Hiyama, Organofluorin Compounds: Chemistry and Application, Springer, Berlin, 2000, pp. 183-234; (d) W.P. Gu, J.H. Lin, J.C. Xiao, Direct N-gem-difluorocyclopropylation of nitroheterocycles by utilizing gem-difluorocyclopropyl tosylate, Chin. Chem. Lett. 25 (2014) 24-28.[1] (a) R. Filler, Y. Kobayashi, L.M. Yagupolskii, Organofluorine Compounds in Medicinal Chemistry and Biomedical Applications, Elsevier, Amsterdam, 1993; (b) R.E. Banks, B.E. Smart, C.J. Tatlow, Organofluorine Chemistry: Principles and Comercial Applications, Springer, New York, 1994, pp. 237-262; (c) T. Hiyama, Organofluorin Compounds: Chemistry and Application, Springer, Berlin, 2000, pp. 183-234; (d) W.P. Gu, J.H. Lin, J.C. Xiao, Direct N-gem-difluorocyclopropylation of nitroheterocycles by utilizing gem-difluorocyclopropyl tosylate, Chin. Chem. Lett. 25 (2014) 24-28.

  2. [2] (a) K. Mü ller, C. Faeh, F. Diederich, Fluorine in pharmaceuticals: looking beyond intuition, Science 317 (2007) 1881-1886; (b) S. Purser, P.R. Moore, S. Swallow, V. Gouverneur, Fluorine in medicinal chemistry, Chem. Soc. Rev. 37 (2008) 320-330; (c) W.K. Hagmann, The many roles for fluorine in medicinal chemistry, J. Med. Chem. 51 (2008) 4359-4369.[2] (a) K. Mü ller, C. Faeh, F. Diederich, Fluorine in pharmaceuticals: looking beyond intuition, Science 317 (2007) 1881-1886; (b) S. Purser, P.R. Moore, S. Swallow, V. Gouverneur, Fluorine in medicinal chemistry, Chem. Soc. Rev. 37 (2008) 320-330; (c) W.K. Hagmann, The many roles for fluorine in medicinal chemistry, J. Med. Chem. 51 (2008) 4359-4369.

  3. [3] H. Kawai, S. Okusu, E. Tokunaga, N. Shibata, Enantioselective synthesis of 5-trifluoromethyl-2-isoxazolines and their N-oxides by ［hydroxy(tosyloxy)iodo］ benzene-mediated oxidative N-O coupling, Eur. J. Org. Chem. 29 (2013) 6506-6509.[3] H. Kawai, S. Okusu, E. Tokunaga, N. Shibata, Enantioselective synthesis of 5-trifluoromethyl-2-isoxazolines and their N-oxides by ［hydroxy(tosyloxy)iodo］ benzene-mediated oxidative N-O coupling, Eur. J. Org. Chem. 29 (2013) 6506-6509.

  4. [4] P.V. Ramachandran, Asymmetric Fluoroorganic Chemistry: synthesis, Application and Future Directions, ACS, Washington, 1999, pp. 255-269.[4] P.V. Ramachandran, Asymmetric Fluoroorganic Chemistry: synthesis, Application and Future Directions, ACS, Washington, 1999, pp. 255-269.

  5. [5] (a) J. Ren, J. Milton, K.L. Weaver, S.A. Short, D.I. Stuart, D.K. Stammers, Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase, Structure 8 (2000) 1089-1094; (b) O.S. Pedersen, E.B. Pedersen, The flourishing syntheses of non-nucleoside reverse transcriptase inhibitors, Synthesis 4 (2000) 479-495.[5] (a) J. Ren, J. Milton, K.L. Weaver, S.A. Short, D.I. Stuart, D.K. Stammers, Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase, Structure 8 (2000) 1089-1094; (b) O.S. Pedersen, E.B. Pedersen, The flourishing syntheses of non-nucleoside reverse transcriptase inhibitors, Synthesis 4 (2000) 479-495.

  6. [6] S. Sasaki, K. Kikuchi, T. Yamuchi, K. Higashiyama, Direct Aldol reaction of trifluoromethyl ketones with ketone catalyzed by Et2Zn and secondary amines, Synlett 10 (2011) 1431-1434.[6] S. Sasaki, K. Kikuchi, T. Yamuchi, K. Higashiyama, Direct Aldol reaction of trifluoromethyl ketones with ketone catalyzed by Et2Zn and secondary amines, Synlett 10 (2011) 1431-1434.

  7. [7] (a) L.H. Qiu, Z.X. Shen, C.Q. Shi, Y.H. Liu, Y.W. Zhang, Proline catalyzed asymmetric Aldol reaction between methyl ketones and 1-aryl-2 2,2-trifluoroethanones, Chin. J. Chem. 23 (2005) 584-588; (b) N. Duangdee, W. Harnying, G. Rulli, et al., Highly enantioselective organocatalytic trifluoromethyl carbinol synthesis -a caveat on reaction times and product isolation, J. Am. Chem. Soc. 134 (2012) 11196-11205; (c) N. Hara, R. Tamura, Y. Funahashi, S. Nakamura, N-(heteroarenesulfonyl) prolinamides-catalyzed Aldol reaction between acetone and aryl trihalomethyl ketones, Org. Lett. 13 (2011) 1662-1665; (d) Y. Zheng, H.Y. Xiong, J. Nie, M.Q. Hua, J.A. Ma, Biomimetic catalytic enantioselective decarboxylative Aldol reaction of β-keto acids with trifluoromethyl ketones, Chem. Commun. 48 (2012) 4308-4310.[7] (a) L.H. Qiu, Z.X. Shen, C.Q. Shi, Y.H. Liu, Y.W. Zhang, Proline catalyzed asymmetric Aldol reaction between methyl ketones and 1-aryl-2 2,2-trifluoroethanones, Chin. J. Chem. 23 (2005) 584-588; (b) N. Duangdee, W. Harnying, G. Rulli, et al., Highly enantioselective organocatalytic trifluoromethyl carbinol synthesis -a caveat on reaction times and product isolation, J. Am. Chem. Soc. 134 (2012) 11196-11205; (c) N. Hara, R. Tamura, Y. Funahashi, S. Nakamura, N-(heteroarenesulfonyl) prolinamides-catalyzed Aldol reaction between acetone and aryl trihalomethyl ketones, Org. Lett. 13 (2011) 1662-1665; (d) Y. Zheng, H.Y. Xiong, J. Nie, M.Q. Hua, J.A. Ma, Biomimetic catalytic enantioselective decarboxylative Aldol reaction of β-keto acids with trifluoromethyl ketones, Chem. Commun. 48 (2012) 4308-4310.

  8. [8] (a) M.A.P. Martins, C.P. Frizzo, D.N. Moreira, L. Buriol, P. Machado, Solvent-free heterocyclic synthesis, Chem. Rev. 109 (2009) 4140-4182; (b) G. Choudhary, R. Krishna Peddinti, An expeditious, highly efficient, catalystfree and solvent-free synthesis of nitroamines and nitrosulfides by Michael addition, Green Chem. 13 (2011) 276-282; (c) A. Kumar, S. Sharma, A grinding-induced catalyst-and solvent-free synthesis of highly functionalized 1,4-dihydropyridines via a domino multicomponent reaction, Green Chem. 13 (2011) 2017-2020; (d) D. Wang, J. Li, N. Li, T. Gao, S. Hou, B. Chen, An efficient approach to homocoupling of terminal alkynes: solvent-free synthesis of 1,3-diynes using catalytic Cu (II) and base, Green Chem. 12 (2010) 45-48; (e) B.R. Vaddula, R.S. Varma, J. Leazer, Mixing with microwaves: solvent-free and catalyst-free synthesis of pyrazoles and diazepines, Tetrahedron Lett. 54 (2013) 1538-1541; (f) J. Yang, N. Li, S. Li, W. Wang, L. Li, A. Wang, X. Wang, Synthesis of diesel and jet fuel range alkanes with furfural and ketones from lignocellulose under solvent free conditions, Green Chem. 16 (2014) 4879-4884; (g) S. Yan, Y. Chen, L. Liu, N. He, J. Lin, Three-component solvent-free synthesis of highly substituted bicyclic pyridines containing a ring-junction nitrogen, Green Chem. 12 (2010) 2043-2052; (h) Y.H. Ma, G. Wu, N. Jiang, et al., Microwave-assisted, facile, rapid and solventfree one pot two-component synthesis of some special acylals, Chin. Chem. Lett. 26 (2015) 81-84.[8] (a) M.A.P. Martins, C.P. Frizzo, D.N. Moreira, L. Buriol, P. Machado, Solvent-free heterocyclic synthesis, Chem. Rev. 109 (2009) 4140-4182; (b) G. Choudhary, R. Krishna Peddinti, An expeditious, highly efficient, catalystfree and solvent-free synthesis of nitroamines and nitrosulfides by Michael addition, Green Chem. 13 (2011) 276-282; (c) A. Kumar, S. Sharma, A grinding-induced catalyst-and solvent-free synthesis of highly functionalized 1,4-dihydropyridines via a domino multicomponent reaction, Green Chem. 13 (2011) 2017-2020; (d) D. Wang, J. Li, N. Li, T. Gao, S. Hou, B. Chen, An efficient approach to homocoupling of terminal alkynes: solvent-free synthesis of 1,3-diynes using catalytic Cu (II) and base, Green Chem. 12 (2010) 45-48; (e) B.R. Vaddula, R.S. Varma, J. Leazer, Mixing with microwaves: solvent-free and catalyst-free synthesis of pyrazoles and diazepines, Tetrahedron Lett. 54 (2013) 1538-1541; (f) J. Yang, N. Li, S. Li, W. Wang, L. Li, A. Wang, X. Wang, Synthesis of diesel and jet fuel range alkanes with furfural and ketones from lignocellulose under solvent free conditions, Green Chem. 16 (2014) 4879-4884; (g) S. Yan, Y. Chen, L. Liu, N. He, J. Lin, Three-component solvent-free synthesis of highly substituted bicyclic pyridines containing a ring-junction nitrogen, Green Chem. 12 (2010) 2043-2052; (h) Y.H. Ma, G. Wu, N. Jiang, et al., Microwave-assisted, facile, rapid and solventfree one pot two-component synthesis of some special acylals, Chin. Chem. Lett. 26 (2015) 81-84.

  9. [9] (a) H.W. Zhan, J.X. Wang, X.T. Wang, Solvent-and catalyst-free synthesis of dihydropyrimidinthiones in one-pot under focused microwave irradiation conditions, Chin. Chem. Lett. 19 (2008) 1183-1185; (b) X.Q. Men, T.J. Meng, J.X. Wang, L. Xin, Pd(II) catalyzed addition reaction of benzylzinc bromides or allylzinc iodines with aromatic aldehydes, Chin. J. Org. Chem. 27 (2007) 272-275; (c) J.X. Wang, N. An, Solvent-free synthesis of 1 4-bis(3-aryl-3-oxo-3-propenyl)-benzenes under grind condition, J. Northw. Norm. Univ. (Nat. Sci.) 47 (2011) 59-62.[9] (a) H.W. Zhan, J.X. Wang, X.T. Wang, Solvent-and catalyst-free synthesis of dihydropyrimidinthiones in one-pot under focused microwave irradiation conditions, Chin. Chem. Lett. 19 (2008) 1183-1185; (b) X.Q. Men, T.J. Meng, J.X. Wang, L. Xin, Pd(II) catalyzed addition reaction of benzylzinc bromides or allylzinc iodines with aromatic aldehydes, Chin. J. Org. Chem. 27 (2007) 272-275; (c) J.X. Wang, N. An, Solvent-free synthesis of 1 4-bis(3-aryl-3-oxo-3-propenyl)-benzenes under grind condition, J. Northw. Norm. Univ. (Nat. Sci.) 47 (2011) 59-62.

  10. [10] J. Xu, Y. Hu, D. Huang, et al., Thiourea-catalyzed enantioselective fluorination ofbketo esters, Adv. Synth. Catal. 354 (2012) 515-526.[10] J. Xu, Y. Hu, D. Huang, et al., Thiourea-catalyzed enantioselective fluorination ofbketo esters, Adv. Synth. Catal. 354 (2012) 515-526.

  11. [11] V.Y. Sosnovskikh, I.S. Ovsyannikov, I.A. Aleksandrova, Ketone-ketone condensation with the participation of polyhaloalkyl phenyl ketones, Zh. Org. Khim. 28 (1992) 518-526.[11] V.Y. Sosnovskikh, I.S. Ovsyannikov, I.A. Aleksandrova, Ketone-ketone condensation with the participation of polyhaloalkyl phenyl ketones, Zh. Org. Khim. 28 (1992) 518-526.

  12. [12] J. Nie, H.C. Guo, D. Cahard, J.A. Ma, Asymmetric construction of stereogenic carbon centers featuring a trifluoromethyl group from prochiral trifluoromethylated substrates, Chem. Rev. 111 (2011) 455-529.[12] J. Nie, H.C. Guo, D. Cahard, J.A. Ma, Asymmetric construction of stereogenic carbon centers featuring a trifluoromethyl group from prochiral trifluoromethylated substrates, Chem. Rev. 111 (2011) 455-529.

  13. [13] (a) G. Rothenberg, A.P. Downie, C.L. Raston, J.L. Scott, Understanding solid/solid organic reactions, J. Am. Chem. Soc. 123 (2001) 8701-8708; (b) T. Friščić , W. Jones, Recent advances in understanding the mechanism of cocrystal formation via grinding, Cryst. Growth Des. 9 (2009) 1621-1637; (c) P.R. Patil, K.P.R. Kartha, Application of ball milling technology to carbohydrate reactions: I. Regioselective primary hydroxyl protection of hexosides and nucleoside by planetary ball milling, J. Carbohydr. Chem. 27 (2008) 279-293.[13] (a) G. Rothenberg, A.P. Downie, C.L. Raston, J.L. Scott, Understanding solid/solid organic reactions, J. Am. Chem. Soc. 123 (2001) 8701-8708; (b) T. Friščić , W. Jones, Recent advances in understanding the mechanism of cocrystal formation via grinding, Cryst. Growth Des. 9 (2009) 1621-1637; (c) P.R. Patil, K.P.R. Kartha, Application of ball milling technology to carbohydrate reactions: I. Regioselective primary hydroxyl protection of hexosides and nucleoside by planetary ball milling, J. Carbohydr. Chem. 27 (2008) 279-293.

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