Solubilization of organic compounds by arginine-derived polymers

Citation: Xuchen Huang, Yanbin Huang. Solubilization of organic compounds by arginine-derived polymers[J]. Chinese Chemical Letters, 2015, 26(6): 636-640. doi: 10.1016/j.cclet.2015.04.009 shu

Solubilization of organic compounds by arginine-derived polymers

Xuchen Huang ,
Yanbin Huang ^,

通讯作者: Yanbin Huang,

基金项目:
This study is supported by the Natural Science Foundation of China (No. 21434008). (No. 21434008)

摘要: Poor aqueous solubility of drugs is one of the major challenges in the pharmaceutical science. In this study, a guanidinium-containing polymer based on arginine was designed and synthesized, and was evaluated as a solubility enhancing additive for three model organic compounds (coumarin, pyrene and doxorubicin). At a guanidinium group concentration of 100 mmol/L, the polymer could significantly increase the solubility of pyrene and doxorubicin by 6-and 11-fold respectively, much more effective than arginine (2-and 3-fold, respectively). In contrast, its effect on the solubility of coumarin was less effective than arginine. The solubilizing effect may be explained by the enhanced interaction between the guanidinium group in the polymer and the aromatic compounds.

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English

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