Novel NO-releasing derivatives of betulinic acid with antitumor activity

Jin-Hong Liu Zi-Fei Zhu Jia Tang Ai-Qin Jiang Liu-Fang Hu Li Chen

Citation:  Jin-Hong Liu, Zi-Fei Zhu, Jia Tang, Ai-Qin Jiang, Liu-Fang Hu, Li Chen. Novel NO-releasing derivatives of betulinic acid with antitumor activity[J]. Chinese Chemical Letters, 2015, 26(6): 759-762. doi: 10.1016/j.cclet.2015.04.002 shu

Novel NO-releasing derivatives of betulinic acid with antitumor activity

    通讯作者: Ai-Qin Jiang,
    Li Chen,
摘要: Thirteen novel NO-releasing derivatives of betulinic acid (BA) bearing two types of NO-donors (nitrates and furoxans) were synthesized and evaluated for their antitumor activity. The results showed that furoxan-based derivatives exhibited higher antitumor activity than nitrate-based derivatives, with compounds 11a and 11b displaying promising potency against B16 cell lines and HepG2 cell lines (IC50 < 1 μmol/L). Wesupposed that NO-releasing amount of these derivatives which can be detected by Griess method may contribute more to their antitumor activity. As a result, furoxan-based derivatives released larger amount of NO than that of nitrate-based derivatives, which partially explained the higher anti-tumor activity of the former.

English

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  • 发布日期:  2015-04-13
  • 收稿日期:  2014-11-20
  • 网络出版日期:  2015-03-17
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