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PEGylated WS2 nanosheets for X-ray computed tomography imaging and photothermal therapy

Xiao-Zhen Cui ,  Zhi-Guo Zhou ,  Yan Yang ,  Jie Wei ,  Jun Wang ,  Ming-Wei Wang ,  Hong Yang ,  Ying-Jian Zhang ,  Shi-Ping Yang

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Citation:  Xiao-Zhen Cui, Zhi-Guo Zhou, Yan Yang, Jie Wei, Jun Wang, Ming-Wei Wang, Hong Yang, Ying-Jian Zhang, Shi-Ping Yang. PEGylated WS2 nanosheets for X-ray computed tomography imaging and photothermal therapy[J]. Chinese Chemical Letters, 2015, 26(6): 749-754. doi: 10.1016/j.cclet.2015.03.034 shu

PEGylated WS2 nanosheets for X-ray computed tomography imaging and photothermal therapy

    • 通讯作者: Zhi-Guo Zhou,
    Ming-Wei Wang,
  • 基金项目:

    Innovative Research Team in University (No. IRT1269) (No. IRT1269)

    Shanghai Pujiang Program (No. 13PJ1406600) (No. 13PJ1406600)

    Shanghai Municipal Education Commission (No. 13ZZ110) (No. 13ZZ110)

    International Joint Laboratory on Resource Chemistry (IJLRC). (IJLRC)

摘要: WS2 nanosheets were prepared by the solvent-thermal method in the presence of n-butyl lithium, then the exfoliation under the condition of ultrasound. The formed WS2 nanosheets were conjugated with thiol-modified polyethylene glycol (PEG-SH) to improve the biocompatibility. The nanosheets (WS2-PEG) were able to inhibit the growth of a model HeLa cancer cell line in vitro due to the high photothermal conversion efficiency of 35% irradiated by an 808 nm laser (1 W/cm2). As a proof of concept, WS2-PEG nanosheets with the better X-ray attenuation property than the clinical computed tomography (CT) contrast agent (Iohexol) could be performed for CT imaging of the lymph vessel.

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  • 发布日期:  2015-04-02
  • 收稿日期:  2014-12-31
  • 网络出版日期:  2015-02-28
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