Microwave-assisted, facile, rapid and solvent-free one pot two-component synthesis of some special acylals

Yu-Heng Ma Gang Wu Nan Jiang Shu-Wang Ge Qian Zhou Bai-Wang Sun

Citation:  Yu-Heng Ma, Gang Wu, Nan Jiang, Shu-Wang Ge, Qian Zhou, Bai-Wang Sun. Microwave-assisted, facile, rapid and solvent-free one pot two-component synthesis of some special acylals[J]. Chinese Chemical Letters, 2015, 26(1): 81-84. doi: 10.1016/j.cclet.2014.11.001 shu

Microwave-assisted, facile, rapid and solvent-free one pot two-component synthesis of some special acylals

    通讯作者: Bai-Wang Sun,
摘要: A facile, rapid and solvent-free method for the conversion of acids and dihalomethane to the corresponding methylene diesters (acylals) using microwave as activators or assistor, is reported. This method is particularly powerful for the diesterification of carboxylic acids, which afford methylene diesters in good to excellent yields (up to >99%). When the intermediate is trapped, a "double successive SN2 reactions" mechanism is proved.

English

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  • 发布日期:  2014-11-10
  • 收稿日期:  2014-06-28
  • 网络出版日期:  2014-10-22
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