Analysis of chloramphenicol in honey by on-line pretreatment liquid chromatography-tandem mass spectrometry

Shin-ichi Kawano Hong-Yuan Hao Yuki Hashi Jin-Ming Lin

Citation:  Shin-ichi Kawano, Hong-Yuan Hao, Yuki Hashi, Jin-Ming Lin. Analysis of chloramphenicol in honey by on-line pretreatment liquid chromatography-tandem mass spectrometry[J]. Chinese Chemical Letters, 2015, 26(1): 36-38. doi: 10.1016/j.cclet.2014.10.026 shu

Analysis of chloramphenicol in honey by on-line pretreatment liquid chromatography-tandem mass spectrometry

    通讯作者: Jin-Ming Lin,
  • 基金项目:

    This work was supported by the National Natural Science Foundation of China (No. 21227006)  (No. 21227006)

    the Research Fund for the Doctoral Program of Higher Education (No. 20110002110052). (No. 20110002110052)

摘要: Chloramphenicol is an antibiotic and one of the potential contaminants in honey. Solid-phase extraction is the key pretreatment procedure for analysis of chloramphenicol in honey. In this work, an on-line pretreatment liquid chromatography-tandem mass spectrometer system for sensitive, reliable and higher throughput analysis was developed. With the methylcellulose-immobilized reversed-phase column, sugars in a honey sample were efficiently removed in 1 min. As a result, the limit of quantitation of chloramphenicol was 20 pg/mL (0.2 mg/kg honey).

English

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  • 发布日期:  2014-11-05
  • 收稿日期:  2014-07-14
  • 网络出版日期:  2014-10-15
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