Facile three-component synthesis and insecticidal evaluation of hexahydroimidazo[1,2-a]pyridine derivatives

Ye-Feng Fan Wen-Wen Zhang Xu-Sheng Shao Zhi-Ping Xu Xiao-Yong Xu Zhong Li

Citation:  Ye-Feng Fan, Wen-Wen Zhang, Xu-Sheng Shao, Zhi-Ping Xu, Xiao-Yong Xu, Zhong Li. Facile three-component synthesis and insecticidal evaluation of hexahydroimidazo[1,2-a]pyridine derivatives[J]. Chinese Chemical Letters, 2015, 26(1): 1-5. doi: 10.1016/j.cclet.2014.10.019 shu

Facile three-component synthesis and insecticidal evaluation of hexahydroimidazo[1,2-a]pyridine derivatives

    通讯作者: Zhong Li,
  • 基金项目:

    This work was supported by National Key Technology R&D Program of China (No. 2011BAE06B01). (No. 2011BAE06B01)

摘要: A series of new hexahydroimidazo[1,2-a]pyridine derivatives were synthesized via convenient and practical three-component reactions. Preliminary bioassays showed that majority of the target compounds exhibited moderate to excellent insecticidal activity against cowpea aphids (Aphis craccivora). Among them, compound 9l demonstrated significant activity with LC50 value of 0.00918 mmol/L which was about 3.8-fold higher than that of imidacloprid (IMI). Furthermore, the study of stereostructure-activity relationship of four isomers of 9k indicated that configuration played a key role in insecticidal activity of these compounds.

English

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  • 发布日期:  2014-11-04
  • 收稿日期:  2014-08-18
  • 网络出版日期:  2014-10-14
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