Copper-catalyzed amide bond formation from formamides and carboxylic acids

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Copper-catalyzed amide bond formation from formamides and carboxylic acids

Hong-Qiang Liu , Jun Liu , Yang-Hui Zhang , Chang-Dong Shao , Jing-Xun Yu

Citation: Hong-Qiang Liu, Jun Liu, Yang-Hui Zhang, Chang-Dong Shao, Jing-Xun Yu. Copper-catalyzed amide bond formation from formamides and carboxylic acids[J]. Chinese Chemical Letters, 2015, 26(1): 11-14. doi: 10.1016/j.cclet.2014.09.007 shu

shu

Copper-catalyzed amide bond formation from formamides and carboxylic acids

通讯作者: Yang-Hui Zhang,

基金项目:
The work was supported by the National Natural Science Foundation of China (No. 21372176) (No. 21372176)

Technology Commission (No. 11 J1409800) (No. 11 J1409800)

the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning. (Eastern Scholar)

摘要: A highly efficient copper-catalyzed approach to form amide bonds from formamides and carboxylic acids was developed. This protocol shows broad substrate scopes and high yields in the presence of 1 mol% catalyst and 4.0 equiv. formamides.

关键词:

English

Copper-catalyzed amide bond formation from formamides and carboxylic acids

1.
a Department of Chemistry, Tongji University, Shanghai 200092, China;
2.
b Key Laboratory of Yangtze River Water Environment, Ministry of Education, Tongji University, Shanghai 200092, China

Corresponding author: Yang-Hui Zhang,

Received Date: 15 May 2014
Available Online: 16 September 2014
Fund Project:

Abstract: A highly efficient copper-catalyzed approach to form amide bonds from formamides and carboxylic acids was developed. This protocol shows broad substrate scopes and high yields in the presence of 1 mol% catalyst and 4.0 equiv. formamides.

Key words:

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