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Multicomponent domino process for the synthesis of some novel 5-(arylidene)-3-((1-aryl-1H-1,2,3-triazol-4-yl)methyl)-thiazolidine-2,4-diones using PEG-400 as an efficient reaction medium and their antimicrobial evaluation

Jayant Sindhu ,  Harjinder Singh ,  J. M. Khurana ,  Chetan Sharma ,  K. R. Aneja

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Citation:  Jayant Sindhu, Harjinder Singh, J. M. Khurana, Chetan Sharma, K. R. Aneja. Multicomponent domino process for the synthesis of some novel 5-(arylidene)-3-((1-aryl-1H-1,2,3-triazol-4-yl)methyl)-thiazolidine-2,4-diones using PEG-400 as an efficient reaction medium and their antimicrobial evaluation[J]. Chinese Chemical Letters, 2015, 26(1): 50-54. doi: 10.1016/j.cclet.2014.09.006 shu

Multicomponent domino process for the synthesis of some novel 5-(arylidene)-3-((1-aryl-1H-1,2,3-triazol-4-yl)methyl)-thiazolidine-2,4-diones using PEG-400 as an efficient reaction medium and their antimicrobial evaluation

    • 通讯作者: J. M. Khurana,
摘要: A series of novel thiazolidinedione-triazole hybrids were synthesized by one pot reaction between thiazolidine-2,4-dione, substituted aryl aldehydes, propargyl bromide and substituted aryl azides using piperidine, CuSO4·5H2O and sodium ascorbate as catalysts in PEG-400 as a highly efficient and green media. These thiazolidinedione-triazole hybrids were subjected to in vitro antibacterial activity against four strains namely, Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and antifungal activity against two fungal strains namely, Aspergillus niger and Aspergillus flavus.

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  • 发布日期:  2014-09-16
  • 收稿日期:  2014-05-16
  • 网络出版日期:  2014-08-29
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