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Chemical compositions and effects on chemiluminescence of AMs in vitro of chalk dusts

Yue-Xia Zhang ,  Zhen-Hua Yang ,  Quan-Xi Zhang ,  Rui-Jin Li ,  Hong Geng ,  Chuan Dong

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Citation:  Yue-Xia Zhang, Zhen-Hua Yang, Quan-Xi Zhang, Rui-Jin Li, Hong Geng, Chuan Dong. Chemical compositions and effects on chemiluminescence of AMs in vitro of chalk dusts[J]. Chinese Chemical Letters, 2015, 26(1): 157-159. doi: 10.1016/j.cclet.2014.08.004 shu

Chemical compositions and effects on chemiluminescence of AMs in vitro of chalk dusts

    • 通讯作者: Hong Geng,
    Chuan Dong,
摘要: The aim of this study was to investigate the chemical compositions of chalk dust and examine the adverse effects of fine chalk particle matters (PM2.5) on rat alveolar macrophages (AMs) in vitro. Morphologies and element concentrations of chalk particles were analyzed using quantitative energydispersive electron probe X-ray microanalysis (ED-EPMA). The oxidative response of AMs exposed to chalk PM2.5 was measured by luminol-dependent chemiluminescence (CL). The results showed that (1) Chalk dust was mainly composed of gypsum (CaSO4), calcite (CaCO3)/dolomite (CaMg(CO3)2), and organic adhesives; (2) Fine chalk particles induced the AM production of CL, which was inhibited by about 90% by diphenyleneiodonium chloride (DPI). Based on these results, we showed that cytotoxicity of chalk PM2.5 may be related to the reactive oxygen species (ROS) generation.

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  • 发布日期:  2014-09-01
  • 收稿日期:  2014-05-05
  • 网络出版日期:  2014-08-25
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