Effi cient and mild cyclization procedures for the synthesis of novel 2-amino-4<i>H</i>-pyran derivatives with potential antitumor activity

Citation: Dao-Cai Wang, Yong-Mei Xie, Chen Fan, Shun Yao, Hang Song. Effi cient and mild cyclization procedures for the synthesis of novel 2-amino-4H-pyran derivatives with potential antitumor activity[J]. Chinese Chemical Letters, 2014, 25(7): 1011-1013. doi: 10.1016/j.cclet.2014.04.026 shu

Effi cient and mild cyclization procedures for the synthesis of novel 2-amino-4H-pyran derivatives with potential antitumor activity

通讯作者: Hang Song,

基金项目:

convenient route to construct more diverse pyran analog libraries. The antitumor activity of the synthesized compounds was evaluated in three human tumor cell lines, including human colon cancer (HCT116) (HCT116)

human cervical cancer (Hela) (Hela)

nonsmall cell lung cancer (H1975). (H1975)

摘要: A series of novel 2-amino-4H-pyran derivatives have been synthesized via a three-component reaction of a, β-unsaturated ketone derivatives, malononitrile, aldehydes in excellent yields, using DBU as a catalyst and ethanol as a cheap, safe, and environmentally benign solvent under mild conditions. Their antitumor activity was evaluated in three human tumor cell lines, including human colon cancer (HCT116), human cervical cancer (Hela), and non-small cell lung cancer (H1975).

关键词:

English

Effi cient and mild cyclization procedures for the synthesis of novel 2-amino-4H-pyran derivatives with potential antitumor activity

1.
a Department of Pharmaceutical and Biological Engineering, College of Chemical Engineering, Sichuan University, Chengdu 610065, China;
2.
b State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China

Corresponding author: Hang Song,

Received Date: 11 March 2014

Abstract: A series of novel 2-amino-4H-pyran derivatives have been synthesized via a three-component reaction of a, β-unsaturated ketone derivatives, malononitrile, aldehydes in excellent yields, using DBU as a catalyst and ethanol as a cheap, safe, and environmentally benign solvent under mild conditions. Their antitumor activity was evaluated in three human tumor cell lines, including human colon cancer (HCT116), human cervical cancer (Hela), and non-small cell lung cancer (H1975).

Key words:

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沈阳化工大学材料科学与工程学院沈阳 110142

Effi cient and mild cyclization procedures for the synthesis of novel 2-amino-4H-pyran derivatives with potential antitumor activity

通讯作者: Hang Song,

English

Effi cient and mild cyclization procedures for the synthesis of novel 2-amino-4H-pyran derivatives with potential antitumor activity

Corresponding author: Hang Song,

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

Effi cient and mild cyclization procedures for the synthesis of novel 2-amino-4H-pyran derivatives with potential antitumor activity

通讯作者: Hang Song,

English

Effi cient and mild cyclization procedures for the synthesis of novel 2-amino-4H-pyran derivatives with potential antitumor activity

Corresponding author: Hang Song,

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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