Synthesis, insecticidal activity and molecular docking study of clothianidin analogues with hydrazide group

注册 English

Synthesis, insecticidal activity and molecular docking study of clothianidin analogues with hydrazide group

Shao-Hua Liu , Wei Peng , Yan-Yan Qu , Dan Xu , Hong-Yue Li , Dun-Lun Song , Hong-Xia Duan , Xin-Ling Yang

Citation: Shao-Hua Liu, Wei Peng, Yan-Yan Qu, Dan Xu, Hong-Yue Li, Dun-Lun Song, Hong-Xia Duan, Xin-Ling Yang. Synthesis, insecticidal activity and molecular docking study of clothianidin analogues with hydrazide group[J]. Chinese Chemical Letters, 2014, 25(7): 1017-1020. doi: 10.1016/j.cclet.2014.03.026 shu

shu

Synthesis, insecticidal activity and molecular docking study of clothianidin analogues with hydrazide group

通讯作者: Xin-Ling Yang,

基金项目:
This work was financially supported by the National Basic Research Program of China (No. 2010CB126104). (No. 2010CB126104)

摘要: A series of novel neonicotinoid analogues were designed and synthesized by introducing a hydrazide group into clothianidin. Their structures were confirmed by IR, ¹H NMR, and HRMS (ESI). Preliminary bioassay showed that some compounds, 5b and 5g, exhibited good activity against soybean aphids (Aphis glycines) at 100 mg L 1. In addition, molecular docking with receptor was carried out to explain their different activity from clothianidin.

关键词:

English

Synthesis, insecticidal activity and molecular docking study of clothianidin analogues with hydrazide group

1.
a Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China;
2.
b Department of Entomology, College of Agriculture and Biotechnology, China Agricultural University, Beijing 100193, China

Corresponding author: Xin-Ling Yang,

Received Date: 18 December 2013
Fund Project:

Abstract: A series of novel neonicotinoid analogues were designed and synthesized by introducing a hydrazide group into clothianidin. Their structures were confirmed by IR, ¹H NMR, and HRMS (ESI). Preliminary bioassay showed that some compounds, 5b and 5g, exhibited good activity against soybean aphids (Aphis glycines) at 100 mg L 1. In addition, molecular docking with receptor was carried out to explain their different activity from clothianidin.

Key words:

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