New cytotoxic C-3 dehydrated bufadienolides from the venom of Bufo bufo gargarizans

Hai-Yan Tian Peng-Wei Zhang Jun-Shan Liu Dong-Mei Zhang Xiao-Qi Zhang Ren-Wang Jiang Wen-Cai Ye

Citation:  Hai-Yan Tian, Peng-Wei Zhang, Jun-Shan Liu, Dong-Mei Zhang, Xiao-Qi Zhang, Ren-Wang Jiang, Wen-Cai Ye. New cytotoxic C-3 dehydrated bufadienolides from the venom of Bufo bufo gargarizans[J]. Chinese Chemical Letters, 2014, 25(7): 1104-1106. doi: 10.1016/j.cclet.2014.02.006 shu

New cytotoxic C-3 dehydrated bufadienolides from the venom of Bufo bufo gargarizans

    通讯作者: Ren-Wang Jiang,
    Wen-Cai Ye,
  • 基金项目:

    This work was supported by National Natural Science Foundation of China (No. 81102518) (No. 81102518)

    Postdoctoral Granted Financial Support (No. 20110490915)  (No. 20110490915)

    the Guangdong High Level Talent Scheme (R.W.J.). (R.W.J.)

摘要: Three new C-3 dehydrated bufadienolides were isolated from the venom of Bufo bufo gargarizans. Their structures were elucidated as 5β,12β-12,14-dihydroxy-11-oxobufa-3,20,22-trienolide (1), 5β,12α-12,14-dihydroxy-11-oxobufa-2,20,22-trienolide (2), and 5β,12β-12,14-dihydroxy-11-oxobufa-2,20,22-trienolide (3) on the basis of extensive spectroscopic analysis, especially 1D NMR and 2D NMR data. In addition, all three compounds were tested for their cytotoxic activities against A549 and HepG2 cancer cell lines. Compounds 2 and 3 showed significant cytotoxicities with IC50 values less than 10 μmol/L on both cancer cells.

English

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  • 收稿日期:  2013-12-31
  • 网络出版日期:  2014-02-13
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