<i>In situ</i> generation of biodegradable poly(<i>p</i>-dioxanone) micro-particles by polymerization in supercritical carbon dioxide

引用本文: Tian Qiang Wang, Xiu Li Zhao, Jian Yuan Hao. In situ generation of biodegradable poly(p-dioxanone) micro-particles by polymerization in supercritical carbon dioxide[J]. Chinese Chemical Letters, 2011, 22(12): 1509-1512. doi: 10.1016/j.cclet.2011.07.011 shu

Citation: Tian Qiang Wang, Xiu Li Zhao, Jian Yuan Hao. In situ generation of biodegradable poly(p-dioxanone) micro-particles by polymerization in supercritical carbon dioxide[J]. Chinese Chemical Letters, 2011, 22(12): 1509-1512. doi: 10.1016/j.cclet.2011.07.011 shu

In situ generation of biodegradable poly(p-dioxanone) micro-particles by polymerization in supercritical carbon dioxide

a State Key Lab of Electronic Films and Integrated Devices, School of Microelectronics and Solid State Electronics University of Electronic Science and Technology of China, Chengdu 610054, China;
b Institute of Chemical Materials, China Academy of Engineering Physics, Mianyang 621900, China
基金项目:
This work was supported by the National Natural Sciences Fund of China (No.30970725) and the Fund of Science and Technology Development from China Academy of Engineering Physics (No.2008A0302012).

摘要: Ring-opening suspension polymerization of p-dioxanone (PDO) in supercritical carbon dioxide (scCO₂) was investigated in the presence of poly (caprolactone)-perfluropolyether-poly (caprolactone) (PCL-PFPE-PCL). The molecular weight, yield and particle morphology of poly (p-dioxanone) (PPDO) were studied. The stabilizer was effective to stabilize the ring-opening polymerization (ROP) of PDO in scCO₂, leading to the formation of resorbable microparticles in a "one pot" procedure. The mean size of PPDO microparticles obtained from suspension polymerizations was sensitive to the rate of agitation and the stabilizer concentration. The method to generate PPDO microparticles has overcome its unprocessable drawback with common organic solvents and provided new product form for biomedical applications.

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English

In situ generation of biodegradable poly(p-dioxanone) micro-particles by polymerization in supercritical carbon dioxide

a State Key Lab of Electronic Films and Integrated Devices, School of Microelectronics and Solid State Electronics University of Electronic Science and Technology of China, Chengdu 610054, China;
b Institute of Chemical Materials, China Academy of Engineering Physics, Mianyang 621900, China
Received Date: 05 May 2011
Fund Project:
This work was supported by the National Natural Sciences Fund of China (No.30970725) and the Fund of Science and Technology Development from China Academy of Engineering Physics (No.2008A0302012).

Abstract: Ring-opening suspension polymerization of p-dioxanone (PDO) in supercritical carbon dioxide (scCO₂) was investigated in the presence of poly (caprolactone)-perfluropolyether-poly (caprolactone) (PCL-PFPE-PCL). The molecular weight, yield and particle morphology of poly (p-dioxanone) (PPDO) were studied. The stabilizer was effective to stabilize the ring-opening polymerization (ROP) of PDO in scCO₂, leading to the formation of resorbable microparticles in a "one pot" procedure. The mean size of PPDO microparticles obtained from suspension polymerizations was sensitive to the rate of agitation and the stabilizer concentration. The method to generate PPDO microparticles has overcome its unprocessable drawback with common organic solvents and provided new product form for biomedical applications.

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In situ generation of biodegradable poly(p-dioxanone) micro-particles by polymerization in supercritical carbon dioxide

English

In situ generation of biodegradable poly(p-dioxanone) micro-particles by polymerization in supercritical carbon dioxide

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In situ generation of biodegradable poly(p-dioxanone) micro-particles by polymerization in supercritical carbon dioxide

English

In situ generation of biodegradable poly(p-dioxanone) micro-particles by polymerization in supercritical carbon dioxide

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

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