引用本文:
Yi Yi Weng, Jian Jun Li, Wei Ke Su. An approach to synthesis of (Z)-2-chloro-l,3-diarylpropen-l-ones by Vilsmeier reagent (bis-(trichloromethyl) carbonate/DMF)[J]. Chinese Chemical Letters,
2011, 22(12): 1395-1398.
doi:
10.1016/j.cclet.2011.07.006
Citation: Yi Yi Weng, Jian Jun Li, Wei Ke Su. An approach to synthesis of (Z)-2-chloro-l,3-diarylpropen-l-ones by Vilsmeier reagent (bis-(trichloromethyl) carbonate/DMF)[J]. Chinese Chemical Letters, 2011, 22(12): 1395-1398. doi: 10.1016/j.cclet.2011.07.006
Citation: Yi Yi Weng, Jian Jun Li, Wei Ke Su. An approach to synthesis of (Z)-2-chloro-l,3-diarylpropen-l-ones by Vilsmeier reagent (bis-(trichloromethyl) carbonate/DMF)[J]. Chinese Chemical Letters, 2011, 22(12): 1395-1398. doi: 10.1016/j.cclet.2011.07.006
An approach to synthesis of (Z)-2-chloro-l,3-diarylpropen-l-ones by Vilsmeier reagent (bis-(trichloromethyl) carbonate/DMF)
摘要:
A series of (Z)-2-chloro-l, 3-diarylpropen-l-ones were unexpectedly synthesized in moderate yields by treatment of easily available 2, 3-epoxy-l, 3-diarylpropan-1 -ones with Vilsmeier reagent, which was derived from bis (trichloromethyl) carbonate (BTC, triphosgene) and DMF. A possible mechanism was also proposed, where sequential ring-opening, halogenation and elimination reactions were involved.
English
An approach to synthesis of (Z)-2-chloro-l,3-diarylpropen-l-ones by Vilsmeier reagent (bis-(trichloromethyl) carbonate/DMF)
Abstract:
A series of (Z)-2-chloro-l, 3-diarylpropen-l-ones were unexpectedly synthesized in moderate yields by treatment of easily available 2, 3-epoxy-l, 3-diarylpropan-1 -ones with Vilsmeier reagent, which was derived from bis (trichloromethyl) carbonate (BTC, triphosgene) and DMF. A possible mechanism was also proposed, where sequential ring-opening, halogenation and elimination reactions were involved.
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