引用本文:
Pu Hua Wu, Qing Qing Meng, Hu Chen Zhou. Synthesis of a novel pyrrolo-benzoxaborole scaffold and its derivatization via Friedel-Crafts reaction catalyzed by anhydrous stannic chloride[J]. Chinese Chemical Letters,
2011, 22(12): 1411-1414.
doi:
10.1016/j.cclet.2011.06.005
Citation: Pu Hua Wu, Qing Qing Meng, Hu Chen Zhou. Synthesis of a novel pyrrolo-benzoxaborole scaffold and its derivatization via Friedel-Crafts reaction catalyzed by anhydrous stannic chloride[J]. Chinese Chemical Letters, 2011, 22(12): 1411-1414. doi: 10.1016/j.cclet.2011.06.005
Citation: Pu Hua Wu, Qing Qing Meng, Hu Chen Zhou. Synthesis of a novel pyrrolo-benzoxaborole scaffold and its derivatization via Friedel-Crafts reaction catalyzed by anhydrous stannic chloride[J]. Chinese Chemical Letters, 2011, 22(12): 1411-1414. doi: 10.1016/j.cclet.2011.06.005
Synthesis of a novel pyrrolo-benzoxaborole scaffold and its derivatization via Friedel-Crafts reaction catalyzed by anhydrous stannic chloride
摘要:
A novel pyrrolo-benzoxaborole, 6-(pyrrol-l-yl)-l, 3-dihydro-l-hydroxy-2, 1-benzoxaborole, was synthesized with 27% overall yield over six steps from 2-bromo-1-methyl-4-nitrobenzene as starting material. Its derivatization was achieved via Friedel-Crafts reaction catalyzed by anhydrous stannic chloride with various acyl chlorides giving 3-acyl-1-phenylpyrroles as the main products.
English
Synthesis of a novel pyrrolo-benzoxaborole scaffold and its derivatization via Friedel-Crafts reaction catalyzed by anhydrous stannic chloride
Abstract:
A novel pyrrolo-benzoxaborole, 6-(pyrrol-l-yl)-l, 3-dihydro-l-hydroxy-2, 1-benzoxaborole, was synthesized with 27% overall yield over six steps from 2-bromo-1-methyl-4-nitrobenzene as starting material. Its derivatization was achieved via Friedel-Crafts reaction catalyzed by anhydrous stannic chloride with various acyl chlorides giving 3-acyl-1-phenylpyrroles as the main products.
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Key words:
- Benzoxaborole
- / Friedel-Crafts reaction
- / Stannic chloride
- / 3-Acyl-1-arylpyrrole
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