引用本文:
Ge Meng, Yao Wu Sha, Rui Zhang, Nan Bai. Mild synthesis of N'-aryl-N,N-dimethylformamidinium chloride by Vilsmeier-Haack reagent[J]. Chinese Chemical Letters,
2011, 22(9): 1043-1046.
doi:
10.1016/j.cclet.2011.03.009
Citation: Ge Meng, Yao Wu Sha, Rui Zhang, Nan Bai. Mild synthesis of N'-aryl-N,N-dimethylformamidinium chloride by Vilsmeier-Haack reagent[J]. Chinese Chemical Letters, 2011, 22(9): 1043-1046. doi: 10.1016/j.cclet.2011.03.009
Citation: Ge Meng, Yao Wu Sha, Rui Zhang, Nan Bai. Mild synthesis of N'-aryl-N,N-dimethylformamidinium chloride by Vilsmeier-Haack reagent[J]. Chinese Chemical Letters, 2011, 22(9): 1043-1046. doi: 10.1016/j.cclet.2011.03.009
Mild synthesis of N'-aryl-N,N-dimethylformamidinium chloride by Vilsmeier-Haack reagent
摘要:
Formamidine derivatives could be used as the building blocks for substituted heterocyclic compounds with various biological activities. N'-Aryl-N, N-dimethylformamidinium chlorides have been synthesized in high yields by reaction of aromatic primary amines with Vilsmeier-Haack reagent at room temperature. The structures of all the new compounds were identified by ESI-MS, IR and NMR spectra. The steric structures of some of these compounds were clarified by X-ray single crystal analysis.
English
Mild synthesis of N'-aryl-N,N-dimethylformamidinium chloride by Vilsmeier-Haack reagent
Abstract:
Formamidine derivatives could be used as the building blocks for substituted heterocyclic compounds with various biological activities. N'-Aryl-N, N-dimethylformamidinium chlorides have been synthesized in high yields by reaction of aromatic primary amines with Vilsmeier-Haack reagent at room temperature. The structures of all the new compounds were identified by ESI-MS, IR and NMR spectra. The steric structures of some of these compounds were clarified by X-ray single crystal analysis.
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Key words:
- Vilsmeier-Haack reagent
- / Formamidinium
- / X-ray single crystal
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