引用本文:
Yu Ming Cui, Lai Lai Wang, Fuk Yee Kwong, Wei Sun. Asymmetric hydrogenation of aromatic ketones using new chiral-bridged diphosphine/diamine-Ru (Ⅱ) complexes[J]. Chinese Chemical Letters,
2010, 21(12): 1403-1406.
doi:
10.1016/j.cclet.2010.05.027
Citation: Yu Ming Cui, Lai Lai Wang, Fuk Yee Kwong, Wei Sun. Asymmetric hydrogenation of aromatic ketones using new chiral-bridged diphosphine/diamine-Ru (Ⅱ) complexes[J]. Chinese Chemical Letters, 2010, 21(12): 1403-1406. doi: 10.1016/j.cclet.2010.05.027
Citation: Yu Ming Cui, Lai Lai Wang, Fuk Yee Kwong, Wei Sun. Asymmetric hydrogenation of aromatic ketones using new chiral-bridged diphosphine/diamine-Ru (Ⅱ) complexes[J]. Chinese Chemical Letters, 2010, 21(12): 1403-1406. doi: 10.1016/j.cclet.2010.05.027
Asymmetric hydrogenation of aromatic ketones using new chiral-bridged diphosphine/diamine-Ru (Ⅱ) complexes
摘要:
A series of chiral secondary alcohols were easily prepared by means of asymmetric hydrogenation of prochiral aromatic ketones using a new ((Rax)-BuP)/(R, R)-DPEN-Ru (Ⅱ) complex catalyst system. The hydrogenation of 2-methylacetophenone in n-butanol (t-BuOK/Ru=45.6/1, S/C=500, 20 atm. Of H2, 20℃, 48h) afforded (S)-1-(2'-methylphenyl) ethanol in 92% ee and>99% conversion.
English
Asymmetric hydrogenation of aromatic ketones using new chiral-bridged diphosphine/diamine-Ru (Ⅱ) complexes
Abstract:
A series of chiral secondary alcohols were easily prepared by means of asymmetric hydrogenation of prochiral aromatic ketones using a new ((Rax)-BuP)/(R, R)-DPEN-Ru (Ⅱ) complex catalyst system. The hydrogenation of 2-methylacetophenone in n-butanol (t-BuOK/Ru=45.6/1, S/C=500, 20 atm. Of H2, 20℃, 48h) afforded (S)-1-(2'-methylphenyl) ethanol in 92% ee and>99% conversion.
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Key words:
- Asymmetric hydrogenation
- / Chiral alcohols
- / Diphosphine ligand
- / Ruthenium complexes
- / Diamine
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