引用本文:
Tian Cai Wang, Ju Zhi Wei, Chuan Sheng Guo, Hui Bin Zhang, Hou Xing Fan. Design,synthesis and anti-proliferative studies of a novel series of indirubin derivatives[J]. Chinese Chemical Letters,
2010, 21(12): 1407-1410.
doi:
10.1016/j.cclet.2010.05.026
Citation: Tian Cai Wang, Ju Zhi Wei, Chuan Sheng Guo, Hui Bin Zhang, Hou Xing Fan. Design,synthesis and anti-proliferative studies of a novel series of indirubin derivatives[J]. Chinese Chemical Letters, 2010, 21(12): 1407-1410. doi: 10.1016/j.cclet.2010.05.026
Citation: Tian Cai Wang, Ju Zhi Wei, Chuan Sheng Guo, Hui Bin Zhang, Hou Xing Fan. Design,synthesis and anti-proliferative studies of a novel series of indirubin derivatives[J]. Chinese Chemical Letters, 2010, 21(12): 1407-1410. doi: 10.1016/j.cclet.2010.05.026
Design,synthesis and anti-proliferative studies of a novel series of indirubin derivatives
摘要:
A series of novel derivatives of indirubin were synthesized and evaluated for their anti-proliferative activity against human cancer cell lines of SGC7901, A549, HL-60, SK-BR-3 and HCT116. Most of the compounds displayed more potent activity than Sunitinib. In addition, the derivatives showed improved water solubility, which may be favorable to their pharmacokinetic performances.
English
Design,synthesis and anti-proliferative studies of a novel series of indirubin derivatives
Abstract:
A series of novel derivatives of indirubin were synthesized and evaluated for their anti-proliferative activity against human cancer cell lines of SGC7901, A549, HL-60, SK-BR-3 and HCT116. Most of the compounds displayed more potent activity than Sunitinib. In addition, the derivatives showed improved water solubility, which may be favorable to their pharmacokinetic performances.
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Key words:
- Anti-proliferative activity
- / Indirubin
- / Sunitinib
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