引用本文:
Guo Qiang Hu, Zhong Quan Zhang, Song Qiang Xie, Wen Long Huang. Synthesis and antitumor evaluation of C3/C3 fluoroquinolone dimers (I):Tethered with a fused heterocyclic s-triazolo [2,1-b] [1,3,4]thiadiazole[J]. Chinese Chemical Letters,
2010, 21(6): 661-663.
doi:
10.1016/j.cclet.2010.01.037
Citation: Guo Qiang Hu, Zhong Quan Zhang, Song Qiang Xie, Wen Long Huang. Synthesis and antitumor evaluation of C3/C3 fluoroquinolone dimers (I):Tethered with a fused heterocyclic s-triazolo [2,1-b] [1,3,4]thiadiazole[J]. Chinese Chemical Letters, 2010, 21(6): 661-663. doi: 10.1016/j.cclet.2010.01.037
Citation: Guo Qiang Hu, Zhong Quan Zhang, Song Qiang Xie, Wen Long Huang. Synthesis and antitumor evaluation of C3/C3 fluoroquinolone dimers (I):Tethered with a fused heterocyclic s-triazolo [2,1-b] [1,3,4]thiadiazole[J]. Chinese Chemical Letters, 2010, 21(6): 661-663. doi: 10.1016/j.cclet.2010.01.037
Synthesis and antitumor evaluation of C3/C3 fluoroquinolone dimers (I):Tethered with a fused heterocyclic s-triazolo [2,1-b] [1,3,4]thiadiazole
摘要:
Five C3/C3 fluoroquinolone dimers tethered with a fused heterocyclic ring of s-triazolo[2,1-b] [1,3,4]thiadiazole derived from antibacterial quinolones were synthesized and characterized, and their in vitro antitumor activity against L1210, CHO cell lines was evaluated via the respective IC50 values.
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关键词:
- Fluoroquinolone
- / Dirtier
- / Antitumor evaluation
English
Synthesis and antitumor evaluation of C3/C3 fluoroquinolone dimers (I):Tethered with a fused heterocyclic s-triazolo [2,1-b] [1,3,4]thiadiazole
Abstract:
Five C3/C3 fluoroquinolone dimers tethered with a fused heterocyclic ring of s-triazolo[2,1-b] [1,3,4]thiadiazole derived from antibacterial quinolones were synthesized and characterized, and their in vitro antitumor activity against L1210, CHO cell lines was evaluated via the respective IC50 values.
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Key words:
- Fluoroquinolone
- / Dirtier
- / Antitumor evaluation
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