Synthesis of 6-sulfamoyl-4-oxoquinoline-3-carboxylic acid derivatives as integrase antagonists with anti-HIV activity

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Synthesis of 6-sulfamoyl-4-oxoquinoline-3-carboxylic acid derivatives as integrase antagonists with anti-HIV activity

Zai Gang Luo , Cheng Chu Zeng , Lei Fu Yang , Hong Qiu He , Cun Xin Wang , Li Ming Hu

引用本文: Zai Gang Luo, Cheng Chu Zeng, Lei Fu Yang, Hong Qiu He, Cun Xin Wang, Li Ming Hu. Synthesis of 6-sulfamoyl-4-oxoquinoline-3-carboxylic acid derivatives as integrase antagonists with anti-HIV activity[J]. Chinese Chemical Letters, 2009, 20(7): 789-792. doi: 10.1016/j.cclet.2009.03.014 shu

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Citation: Zai Gang Luo, Cheng Chu Zeng, Lei Fu Yang, Hong Qiu He, Cun Xin Wang, Li Ming Hu. Synthesis of 6-sulfamoyl-4-oxoquinoline-3-carboxylic acid derivatives as integrase antagonists with anti-HIV activity[J]. Chinese Chemical Letters, 2009, 20(7): 789-792. doi: 10.1016/j.cclet.2009.03.014 shu

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Synthesis of 6-sulfamoyl-4-oxoquinoline-3-carboxylic acid derivatives as integrase antagonists with anti-HIV activity

College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China
基金项目:
The authors gratefully thank the financial supports of the National Basic Research Program (No.2009CB930200) and the Fund from Beijing City Education Committee (No.KM200610005029) and Funding Project for Academic Human Resources Development in Institutions of Higher Learning Under the Jurisdiction of Beijing Municipality.

摘要: A series of novel 6-sulfamoyl-4-oxoquinoline-3-carboxylic acids derivatives have been synthesized and screened for HIV integrase inhibition activity. Their structures were confirmed by ESI-MS,¹H NMR and ¹³C NMR.

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沈阳化工大学材料科学与工程学院沈阳 110142

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