引用本文:
Hua Bing Zhang, Ji Jun Xue, Xiao Long Zhao, De Gang Liu, Ying Li. Synthesis and biological evaluation of novel steroid-linked nitrogen mustards[J]. Chinese Chemical Letters,
2009, 20(6): 680-683.
doi:
10.1016/j.cclet.2009.01.023
Citation: Hua Bing Zhang, Ji Jun Xue, Xiao Long Zhao, De Gang Liu, Ying Li. Synthesis and biological evaluation of novel steroid-linked nitrogen mustards[J]. Chinese Chemical Letters, 2009, 20(6): 680-683. doi: 10.1016/j.cclet.2009.01.023
Citation: Hua Bing Zhang, Ji Jun Xue, Xiao Long Zhao, De Gang Liu, Ying Li. Synthesis and biological evaluation of novel steroid-linked nitrogen mustards[J]. Chinese Chemical Letters, 2009, 20(6): 680-683. doi: 10.1016/j.cclet.2009.01.023
Synthesis and biological evaluation of novel steroid-linked nitrogen mustards
摘要:
Two novel steroid-linked nitrogen mustard conjugates 1a and 1b were synthesized by using estrogenic acid 4 coupled with aniline mustard 8 and phenol mustard 13 in an esterification or amidation procedure. Preliminary cytotoxic screening on cancer cell lines in vitro showed that, the steroid-ester linked nitrogen mustard conjugate 1a exhibited obvious increasing of activities.
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关键词:
- Steroid
- / Nitrogen mustards
- / Synthesis
- / Biological activity
English
Synthesis and biological evaluation of novel steroid-linked nitrogen mustards
Abstract:
Two novel steroid-linked nitrogen mustard conjugates 1a and 1b were synthesized by using estrogenic acid 4 coupled with aniline mustard 8 and phenol mustard 13 in an esterification or amidation procedure. Preliminary cytotoxic screening on cancer cell lines in vitro showed that, the steroid-ester linked nitrogen mustard conjugate 1a exhibited obvious increasing of activities.
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Key words:
- Steroid
- / Nitrogen mustards
- / Synthesis
- / Biological activity
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