引用本文:
Chan Yu Zhang, Yan Feng Luo, Su Jun Wang, Zhao Liu, Yuan Liang Wang, Zhi Qing Liang. Design,synthesis and characterization of novel biodegradable macrodiols based on poly(DL-lactic acid) and poly (p-dioxanone)[J]. Chinese Chemical Letters,
2009, 20(6): 743-746.
doi:
10.1016/j.cclet.2008.12.055
Citation: Chan Yu Zhang, Yan Feng Luo, Su Jun Wang, Zhao Liu, Yuan Liang Wang, Zhi Qing Liang. Design,synthesis and characterization of novel biodegradable macrodiols based on poly(DL-lactic acid) and poly (p-dioxanone)[J]. Chinese Chemical Letters, 2009, 20(6): 743-746. doi: 10.1016/j.cclet.2008.12.055
Citation: Chan Yu Zhang, Yan Feng Luo, Su Jun Wang, Zhao Liu, Yuan Liang Wang, Zhi Qing Liang. Design,synthesis and characterization of novel biodegradable macrodiols based on poly(DL-lactic acid) and poly (p-dioxanone)[J]. Chinese Chemical Letters, 2009, 20(6): 743-746. doi: 10.1016/j.cclet.2008.12.055
Design,synthesis and characterization of novel biodegradable macrodiols based on poly(DL-lactic acid) and poly (p-dioxanone)
摘要:
Integrating poly(lactic acid) (PLA), glycolic acid (GA) and ethylene glycol (EG) will hopefully result in a novel copolymer that combines such advantages as fastened and controllable release rate and improved flexibility together with good biocompatibility. In this study, p-dioxanone (PDO) was employed to copolymerize with DL-lactide (LA) via ring-opening melt polymerization using Sn(Oct)2 as an initiator and ethylene glycol as a co-initiator. The obtained degradable macrodiols (HO-P(LA-co-PDO)-OH) were just such a copolymer consisting of PLA, GA and EG. 1H NMR was employed to characterize the copolymers, and the effect of PDO/LA molar ratios in the feedstock on the molecular weights of HO-P(LA-co-PDO)-OH was investigated by means of endhydroxyl analysis, 1H NMR or GPC-MALLs. The results confirmed the successful synthesis of HO-P(LA-co-PDO)-OH and revealed that one end-hydroxyl of the micarodiols was donated by LA or PDO and the other one by the co-initiator EG. In addition,the molecular weights of HO-P(LA-co-PDO)-OH increased with decreasing PDO/LA ratios.
English
Design,synthesis and characterization of novel biodegradable macrodiols based on poly(DL-lactic acid) and poly (p-dioxanone)
Abstract:
Integrating poly(lactic acid) (PLA), glycolic acid (GA) and ethylene glycol (EG) will hopefully result in a novel copolymer that combines such advantages as fastened and controllable release rate and improved flexibility together with good biocompatibility. In this study, p-dioxanone (PDO) was employed to copolymerize with DL-lactide (LA) via ring-opening melt polymerization using Sn(Oct)2 as an initiator and ethylene glycol as a co-initiator. The obtained degradable macrodiols (HO-P(LA-co-PDO)-OH) were just such a copolymer consisting of PLA, GA and EG. 1H NMR was employed to characterize the copolymers, and the effect of PDO/LA molar ratios in the feedstock on the molecular weights of HO-P(LA-co-PDO)-OH was investigated by means of endhydroxyl analysis, 1H NMR or GPC-MALLs. The results confirmed the successful synthesis of HO-P(LA-co-PDO)-OH and revealed that one end-hydroxyl of the micarodiols was donated by LA or PDO and the other one by the co-initiator EG. In addition,the molecular weights of HO-P(LA-co-PDO)-OH increased with decreasing PDO/LA ratios.
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Key words:
- Macrodiol
- / Poly(lactici acid)
- / p-Dioxanone
- / Ethylene glycol
- / Drug delivery carrier
- / Bone morphogenetic protein
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