Microwave-prompted rapid and efficient synthesis of 3-alkyl substituted imidazo[1,5-a] pyridines

Lai Bao Wang Jia Pan Can Ling Tang Xiu Ren Bu Jie Wang

引用本文: Lai Bao Wang,  Jia Pan,  Can Ling Tang,  Xiu Ren Bu,  Jie Wang. Microwave-prompted rapid and efficient synthesis of 3-alkyl substituted imidazo[1,5-a] pyridines[J]. Chinese Chemical Letters, 2007, 18(4): 390-392. doi: 10.1016/j.cclet.2007.02.015 shu
Citation:  Lai Bao Wang,  Jia Pan,  Can Ling Tang,  Xiu Ren Bu,  Jie Wang. Microwave-prompted rapid and efficient synthesis of 3-alkyl substituted imidazo[1,5-a] pyridines[J]. Chinese Chemical Letters, 2007, 18(4): 390-392. doi: 10.1016/j.cclet.2007.02.015 shu

Microwave-prompted rapid and efficient synthesis of 3-alkyl substituted imidazo[1,5-a] pyridines

  • 基金项目:

    This work is financially supported by the Jiangsu Provincial Natural Science Foundation of China (No. BK2004092),the Scientific Research Foundation for the Returned Overseas Chinese Scholars from State Education Ministry of China,and Nanjing University Talent Development Foundation.

摘要: Under regular heating and microwave irradiation, 3-alkyl substituted imidazo[1,5-a] pyridines were synthesized from 2,2'-pyridil, di-2-pyridyl ketone and aliphatic aldehydes in the presence of ammonium acetate and acetic acid. Compared to the traditional heating condition, the reaction time under microwave irradiation was shorter and 3-alkyl imidazo[1,5-a]pyridines were given in higher yield.

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  • 收稿日期:  2006-11-13
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