引用本文:
Qiu Qin He, Chao Mei Liu, Ke Li, Yong Bing Cao. Design,synthesis of novel antifungal triazole derivatives with high activities against Aspergillus fumigatus[J]. Chinese Chemical Letters,
2007, 18(4): 421-423.
doi:
10.1016/j.cclet.2007.02.011
Citation: Qiu Qin He, Chao Mei Liu, Ke Li, Yong Bing Cao. Design,synthesis of novel antifungal triazole derivatives with high activities against Aspergillus fumigatus[J]. Chinese Chemical Letters, 2007, 18(4): 421-423. doi: 10.1016/j.cclet.2007.02.011
Citation: Qiu Qin He, Chao Mei Liu, Ke Li, Yong Bing Cao. Design,synthesis of novel antifungal triazole derivatives with high activities against Aspergillus fumigatus[J]. Chinese Chemical Letters, 2007, 18(4): 421-423. doi: 10.1016/j.cclet.2007.02.011
Design,synthesis of novel antifungal triazole derivatives with high activities against Aspergillus fumigatus
摘要:
Based on the active site of Aspergillus fumigatus lanosterol 14α-demethylase (AF-CYP51), novel triazole compounds were designed. Their chemical synthesis and the antifungal activities were reported. The results showed that all the target compounds exhibited excellent activities with broad spectrum;in which compounds 4, 12 and 15 showed comparable activities against A.fumigatus to the control drug itraconazole.
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关键词:
- CYP51
- / Antifungal
- / Triazole
- / Synthesis
- / Aspergillus fumigatus
English
Design,synthesis of novel antifungal triazole derivatives with high activities against Aspergillus fumigatus
Abstract:
Based on the active site of Aspergillus fumigatus lanosterol 14α-demethylase (AF-CYP51), novel triazole compounds were designed. Their chemical synthesis and the antifungal activities were reported. The results showed that all the target compounds exhibited excellent activities with broad spectrum;in which compounds 4, 12 and 15 showed comparable activities against A.fumigatus to the control drug itraconazole.
-
Key words:
- CYP51
- / Antifungal
- / Triazole
- / Synthesis
- / Aspergillus fumigatus
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