引用本文:
Feng Zhi Liu, Hao Fang, Wen Fang Xu. An efficient way to coupling amine with derivatives of steric N-Boc-pyrrolidine-2-carboxylic acid[J]. Chinese Chemical Letters,
2007, 18(4): 393-396.
doi:
10.1016/j.cclet.2007.01.048
Citation: Feng Zhi Liu, Hao Fang, Wen Fang Xu. An efficient way to coupling amine with derivatives of steric N-Boc-pyrrolidine-2-carboxylic acid[J]. Chinese Chemical Letters, 2007, 18(4): 393-396. doi: 10.1016/j.cclet.2007.01.048
Citation: Feng Zhi Liu, Hao Fang, Wen Fang Xu. An efficient way to coupling amine with derivatives of steric N-Boc-pyrrolidine-2-carboxylic acid[J]. Chinese Chemical Letters, 2007, 18(4): 393-396. doi: 10.1016/j.cclet.2007.01.048
An efficient way to coupling amine with derivatives of steric N-Boc-pyrrolidine-2-carboxylic acid
摘要:
An efficient way to coupling amine with the derivatives of steric N-Boc-pyrrolidine-2-carboxylic acid was reported in this paper.We have found that the synthesis of derivatives is problematic with the commonly used DCC/HOBT method. As a substitute, the mixed anhydride method was adopted. A series of 6-(3-nitroguanidino)hexanamidopyrrolidine derivatives were prepared with this method.
English
An efficient way to coupling amine with derivatives of steric N-Boc-pyrrolidine-2-carboxylic acid
Abstract:
An efficient way to coupling amine with the derivatives of steric N-Boc-pyrrolidine-2-carboxylic acid was reported in this paper.We have found that the synthesis of derivatives is problematic with the commonly used DCC/HOBT method. As a substitute, the mixed anhydride method was adopted. A series of 6-(3-nitroguanidino)hexanamidopyrrolidine derivatives were prepared with this method.
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