引用本文:
Xue Fei Yan, Ling Yi Kong. Synthesis of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives[J]. Chinese Chemical Letters,
2007, 18(4): 380-382.
doi:
10.1016/j.cclet.2007.01.018
Citation: Xue Fei Yan, Ling Yi Kong. Synthesis of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives[J]. Chinese Chemical Letters, 2007, 18(4): 380-382. doi: 10.1016/j.cclet.2007.01.018
Citation: Xue Fei Yan, Ling Yi Kong. Synthesis of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives[J]. Chinese Chemical Letters, 2007, 18(4): 380-382. doi: 10.1016/j.cclet.2007.01.018
Synthesis of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives
摘要:
A series of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives have been synthesized by utilizing the coupling of methyl 3-methoxy-4-hydroxy-5-bromocinnamate with cuprous phenylacetylide as the key step. The structures of the new compounds were confirmed by 1H NMR, IR and MS. The structure of compound 14 was further confirmed by single crystal X-ray. Compound 17 showed cytotoxic activity against human lung carcinoma A549.
English
Synthesis of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives
Abstract:
A series of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives have been synthesized by utilizing the coupling of methyl 3-methoxy-4-hydroxy-5-bromocinnamate with cuprous phenylacetylide as the key step. The structures of the new compounds were confirmed by 1H NMR, IR and MS. The structure of compound 14 was further confirmed by single crystal X-ray. Compound 17 showed cytotoxic activity against human lung carcinoma A549.
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Key words:
- 2-Aryl-5-alkyl-7-methoxylbenzo[b]furan
- / Neolignans
- / Synthesis
- / Cytotoxicity
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