承业院士与有机磷化学
袁帅, 袁耀锋
【大学化学】doi: 10.12461/PKU.DXHX202409123
袁承业是中国萃取剂化学研究的奠基者,在“两弹一星”等国防任务需求下,成功研制出关键萃取剂如P204 (双(2-乙基己基)磷酸酯)、p350 (甲基膦酸二甲庚酯)等。他还结合有色金属综合利用情况,研制出多种磷萃取剂如P507 (2-乙基已基膦酸-2-乙基已基酯)。袁承业先生团队在大量实验数据的基础上对萃取剂的结构和性能进行了研究,并通过量子化学、分子力学、热力学以及其他测试手段等进行了深入分析,将有机磷萃取剂的化学性能提升至一个新的高度。这些研究为萃取剂的设计与优化提供了坚实的理论基础,同时也推动了工业应用的发展。
关键词: 有机磷化学, 萃取剂, 科学家精神, 核燃料
以“铂的抗癌功能发现”为载体的药事管理专业药物化学课程思政实践
于小轩, 刘武昆
【大学化学】doi: 10.12461/PKU.DXHX202405200
药物化学是药事管理专业的重要课程,本文以“顺铂的抗癌功能发现”为载体,深入挖掘抗肿瘤药物的思政案例,以顺铂为例,延伸至金属类药物,并对其他机制类抗肿瘤药物进行探讨,总结其相关作用靶点及抗肿瘤机制,体现抗肿瘤药物的多样性。本课程通过采用系统讲授和案例教学相结合,翻转课堂等教学方式来调动学生的学习兴趣,并将课程思政理念贯彻教学过程,提高教学效果。本教学模式旨在锻炼学生创新思维、提高学生实践能力、强化学生思政意识。
关键词: 案例教学, 抗癌药物, 金属药物, 课程思政
cis/trans-Octahedral configuration induced topologically different MOFs: Syntheses, structures, and Hirshfeld surface analyses
Ri PENG, Yingxiang BAI, Yuxin XIE, Dunru ZHU
【无机化学学报】doi: 10.11862/CJIC.20250143
Two metal-organic frameworks (MOFs), trans-[Co(L)(μ2-H2O)(H2O)2]·2H2O (1) and cis-[Mn(L)(Bipy)] (2) (H2L=2, 2′-dimethyl-4, 4′-biphenyldicarboxylic acid, Bipy=4, 4′-bipyridine), have been synthesized and characterized by FTIR, thermogravimetric analysis (TGA), powder and single crystal X-ray diffraction. MOF 1 crystallizes in the triclinic system with a P1 space group and contains two crystallographically different Co(Ⅱ) ions. Each trans-[CoO6] octahedron is connected by μ2-H2O and L2- ligand with a bis(unidentate) coordination mode to produce a 2D sql topological network. MOF 2 crystallizes in the monoclinic system with a C2/c space group. The Mn(Ⅱ) cation adopts a cis-[MnO4N2] octahedron as a 6-connected node and is linked by L2- ligand as a 4-connected node to generate a binodal (4, 6)-connected 3D fsc framework. The intermolecular interactions in 1 and 2 have been investigated by 3D Hirshfeld surface analyses and 2D fingerprint plots to reveal that the main interactions are H…H and O…H/H…O contacts in 1, and H…H and C…H/H…C contacts in 2. The TGA indicated that 1 and 2 were stable below 390 and 370 ℃, respectively.
关键词: metal-organic framework, 2, 2′-dimethyl-4, 4′-biphenyldicarboxylic acid, cis/trans-octahedron, topology, Hirshfeld surface analysis

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