Citation: Du Yulin, Liang Jing. Advances in the Application of Aptamers in Tumor Targeted Therapy[J]. Chemistry, ;2017, 80(9): 809-818, 862. shu

Advances in the Application of Aptamers in Tumor Targeted Therapy

Du Yulin ,
Liang Jing ^,

School of Chemical Engineering & Technology, China University of Mining and Technology, Xuzhou 221116

Corresponding author: Liang Jing, liangjing@cumt.edu.cn
Received Date: 26 March 2017
Accepted Date: 11 May 2017

Figures(4)

Traditional anti-tumor drugs can cause serious side effects in clinical treatment due to their nonspecific toxicity. Aptamers are a class of small nucleic acid ligands that have high affinity and specificity for their targets. Well-characterized biomarkers, especially those closely related to the development of cancer, can be used as targets for aptamer selection via the SELEX method. The newly obtained aptamers may be able to act as drugs themselves, or conjugate with other chemical drugs, siRNA, and nanoparticles to generate targeted drug delivery systems which can target specific tumor cells, thus minimizing the toxicity to normal cells, reducing the dose needed for treatment and enhancing therapeutic efficacy. In this review, we summarize the current advances in the application of aptamers in tumor targeted therapy with aptamers as anti-tumor drugs, as drug carriers, as RNA-based therapeutic carriers or as targeted ligands for conjugates with nanoparticles.
- Aptamer,
- Anti-tumour drug,
- Targeted therapy,
- Nanomaterial,
- siRNA
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